Senior Research Investigator (Cancer Resistance Biology)

The Senior Research Investigator Cancer Resistance Biology will join the Oncology Discovery Research team at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immunobiology.

The qualified candidate is a highly motivated, interactive, and creative individual that possesses substantial experience in studying tumor biology and genetics, especially with respect to how these features impact immune responses to the tumor. The candidate will be expected to effectively collaborate with colleagues in the oncology, immunology, immuno-oncology, protein engineering/antibody development and medicinal chemistry groups. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams, senior management and at external scientific meetings. The candidate will develop external partnerships/collaborations to advance internal programs and the understanding of the interplay between tumor genetics and anti-tumor immune responses as well as publish to advance our science and support our scientific reputation. This individual will demonstrate the ability to contribute to various projects outside of his/her own, and collaborate with stakeholders from all relevant functions. S/he will keep up-to-date in the literature related to his/her field, act as an expert resource in his/her scientific field and in related disciplines, and propose new therapeutic targets. This position is located in Cambridge, MA.

Qualifications

Required

• A Ph.D. degree with 4+ years post-doctoral experience in cancer biology and genetics or a closely related field
• A proven track record in the field of cancer biology and genetics, as evidenced by publication record
• Demonstrated ability to design in vitro and in vivo systems, assays and flowcharts to identify and optimize drug candidates; key technical skills include proficiency in molecular biology techniques and genomics, cellular pharmacodynamics assay design, design and interpretation of pharmacology experiments (PK. PD and efficacy)
• Excellent interpersonal skills with the ability to interact effectively with people, internally and externally
• Excellent oral and written communication skills
• Able to effectively present scientific data and concepts to international standards

Preferred

• Industry experience is highly desired
• Extensive experience in novel preclinical in vitro , in vivo and ex vivo oncology model development, including modified human and murine tumor cell lines for use in mouse xenograft and immunocompetent murine systems (including human immune reconstituted systems)
• Demonstrated expertise to independently apply bioinformatics and data mining through multi-variate analysis; ability to effectively interact with core bioinformatics colleagues, as well as to use desktop tools/interfaces (e.g., Oncoland, Wuxi) and public databases (CBIO, Achilles, etc.)
• Experience in the design, validation and execution of genetic and/or phenotypic screens
• Experience managing external collaborations
• Management/supervisory experience is ideal

Reports:

2-3 Research Scientists/Associates