Our client, a leader in pharmaceuticals, is seeking a Nanoparticle Formulation Scientist. The successful candidate will design and manufacture lipid nanoparticles for the delivery of nucleic acids to mammalian cells as well as other novel nanoparticle-based drug delivery formulations containing small molecules, RNA, DNA and proteins.
- The work is multi-functional and includes formulation design, analytical methods development, physical characterization, experimental design, sample analysis and interpretation of results.
- The candidate with be expected to oversee the synthesis of novel excipients and interact closely with other researchers in the design of lipid nanoparticle delivery formulations.
- This is a hands-on, laboratory-based role in a highly collaborative early development environment.
- Must have experience with lipid nanoparticle delivery of RNA or DNA for transfection to mammalian cells.
- Must have experience in nanoparticle formulation and nanoparticle drug delivery.
- Must have knowledge of the design, synthesis, characterization and structure-property relationships of lipids and other lipid-like molecules used as transfection agents.
- Background in the biology of plasmid transfection and expression is a plus.
- Experience and technical proficiency with HPLC, gel-based and other methods for analysis and quantification of small molecules, DNA and proteins is preferred.
- Previous experience and technical proficiency in the physical characterization of nanoparticles, including particle sizing is a plus.
- Familiarity with lab-scale nanoparticle preparation techniques, including microfluidics technology, is preferred.
- Experience with alternate pharmaceutical manufacturing technologies homogenization, lyophilization, micronization, etc. is a plus.
- Strong interpersonal, communication, collaboration and problem solving skills.
- Ability to document work and proven record of scientific technical writing.
- Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, Biomedical Engineering or closely-related discipline with an emphasis in delivery of nucleic acids.
- M.S. or B.S. in similar fields acceptable with a minimum of 6+ years of relevant industrial experience.