Scientist/Senior Scientist Antibody Engineering

Scientist/Senior Scientist Antibody Engineering

SystImmune, is a fast-growing antibody therapeutics company located in Redmond, Washington, and we are seeking a highly-motivated scientist to support our antibody discovery and engineering efforts. The ideal candidate will have a deep understanding and experience with early-stage drug discovery as it pertains to antibodies and antibody-based biotherapeutics, especially multi-specific and ADC platforms. The candidate must show a meticulous level of detail with the ability to generate timely results with a high degree of accuracy and reproducibility. Priorities will revolve around timeline driven assessment of new therapeutic targets, reagent proteins and proof-of-concept molecules.

Responsibilities: 

• Position requires expertise in molecular biology and protein biochemistry to design, construct, express and characterize antibody-based biotherapeutics and reagent proteins.
• Isolate, sequence, and clone antibody variable region domain genes from rabbit, mouse, or human B cells
• Humanization of antibody variable region genes
• Execute cloning of recombinant antibody and protein expression constructs
• Perform small-scale Fab and IgG expression and purification
• Perform antibody characterization using biolayer interferometry (Octet), ELISA, FACS, SDS-PAGE and Western blot.
• Maintain a current understanding of applicable technologies for ADC and bispecific proteins.
• Analyze, interpret, and document experiments.
• Present results within a multi-disciplinary team environment.
• Strong attention to detail.
• Exceptional level of organization.
• Comfortable working in a fast paced, highly collaborative, dynamic work environment.
• Ability to think creatively and solve problems.

Qualifications:

• PhD with 5+ years, or a MSc. with 8+ years, or a BSc. with 10+ years of experience in a relevant field in the biotechnology sector.
• Deep understanding of antibody structure and biology is required.
• Extensive experience with PCR methods, cloning and other common molecular biology techniques is required.
• Experience with surface plasmon resonance or biolayer interferometry strongly preferred.
• Strong skills in structural biology and rational design preferred, but not required.
• Experience with multiple protein expression systems a plus.
• Demonstrate strong organizational and sample-tracking skills.   
• Ability to work collaboratively as part of a team.
• Previous project management experience is a plus.
• Experience with Microsoft Office, GraphPad Prism, Tableau and JMP a plus.

Interested applicants should send their CV and cover letter to hr@systimmune.com  

SystImmune is a stable, well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including; 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 10 paid holidays and MORE.

SystImmune is an Equal Opportunity Employer. Interested applicants should send their CV and cover letter to hr@systimmune.com