Senior Scientist I, Protein Analytics

Employer
AbbVie
Location
Worcester, MA, US
Posted
Jan 12, 2019
Ref
1900279
Required Education
Masters Degree/MBA
Position Type
Full time
AbbVie is searching for a highly motivated individual to fill a Sr. Scientist I position in the Protein Analytics group at AbbVie Bioresearch Center in Worcester MA. The Protein Analytics Department is responsible for the development, qualification and execution of analytical methods to provide product and process understanding for biological entities from discovery through commercial stages.

The candidate will be part of the Biomolecular Interactions Group within Protein Analytics that is mainly focused on method development and implementation of various immunoassays to monitor process impurities and to assess potency of AbbVie's Biologics. Some other techniques/methods utilized in the group include 1) surface plasmon resonance using Biacore for assessment of antigen binding and binding of antibody Fc receptors; 2) qPCR to measure levels of residual DNA and mycoplasma and 3) SDS-PAGE/immunoblots.

The successful candidate will contribute to the development and testing of potency and impurity assays and will contribute to the continuous improvement and innovation within the group.

Key Responsibilities:

  • Develop, optimize and qualify ELISA methods to examine biomolecular interactions and monitor process-related impurities
  • Address and solve technical problems independently
  • Contribute to host cell protein control strategy and risk assessment
  • Contribute to structure-function relationship study to enhance product understanding
  • Represent analytical function in CMC group setting and work collaboratively to drive biological program development
  • Provide project updates and results to cross-functional team and management in both oral and written communication
  • Conceive and implement innovative ideas, evaluate and integrate state-of-the-art technology to improve work process, and demonstrate a high level of scientific initiative
  • Author technical reports, support and contribute to regulatory filings
  • Organize and document data and results in an electronic lab notebook
  • Efficient IT skills (MS office, in particular EXCEL, other software to support work)
  • May author or co-author peer-reviewed scientific papers or patents


  • BS, MS or PhD degree in biological sciences with 10+ (BS), 8+ (MS) or 0+ (PhD) years of relevant experience in academic or biotech/pharmaceutical industry setting or equivalent
  • Minimum of 5 years hands-on experience with ELISA and other relevant assays required
  • Sound scientific understanding of immunoassays
  • Demonstrated record of independent thought, creativity and scientific accomplishment (e.g. peer reviewed journal publications, patents)
  • Experience or knowledge of the process for generating host cell protein ELISA reagents a plus
  • Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions
  • Goal oriented team player, with problem solving skills, critical thinking ability, and excellent communication skills
  • Highly motivated and independent with an ability to adapt to changing priorities in a fast-paced environment
  • Excellent documentation skills: documents work
  • Automation experience (ie Tecan), and experience with FRET, HTRF, and 2D gels/westerns a plus
  • Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials


Key Leadership Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
  • Learns fast, grasps the "essence" and can change course quickly where indicated
  • Raises the bar and is never satisfied with the status quo
  • Creates a learning environment, open to suggestions and experimentation for improvement
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality


Equal Opportunity Employer Minorities/Women/Veterans/Disabled