Associate Scientist II/ Scientist I, In Vivo Antibody Discovery

Employer
AbbVie
Location
Worcester, MA, US
Posted
Jan 10, 2019
Ref
1900118
Required Education
Bachelors Degree
Position Type
Full time
The Biologics Generation Group within Global Biologics is seeking a highly motivated research scientist to join the in vivo antibody discovery team at AbbVie Bioresearch Center (ABC). The ABC site, based in Worcester, MA, offers the unique setting where Biologics drug discovery, development and manufacturing coexist in one location. Our team interacts with multidisciplinary teams across AbbVie focused on developing therapies for Immunology, Neurology and Oncology diseases. We utilize innovative immunization approaches, advanced multiplex screening assays and best-in-class automation platforms to enable successful antibody discovery against complex targets.

As an integral part of the group, the ideal candidate will:

  • Enable projects through purification and analytical characterization of monoclonal antibodies using traditional and high throughput methods
  • Exercise proficiencies in mammalian tissue culture, molecular techniques, and binding assays, such as ELISA and flow cytometry
  • Execute all phases of in vivo antibody discovery campaigns by hybridoma generation or single cell isolation including immunizations, screening, cell culture and antibody characterization
  • Analyze and document results, placing data in proper scientific context through review of relevant literature and comfortably reporting these findings at team meetings
  • Demonstrate scientific excellence through dedication to multiple projects in a fast-paced multi-disciplinary environment


Position will be hired based on level of experience.

  • BS or MS in Biology or other related field with 3-5+ years (BS), or 0-2+ years (MS) of industry/academic experience
  • Proficient in mammalian cell culture, aseptic technique is required
  • Understanding of immunoassays (e.g. flow cytometry and ELISA)
  • Strong attention to quality and details when exercising organizational, documentation and communication skills
  • Competency with software programs, including MS Excel, Powerpoint, Word


Desirable:

  • Experience with protein purification and in vitro analytical techniques for protein characterization (e.g., SEC, MS)
  • Animal handling experience (e.g. restraint, immunizations, etc.)
  • Molecular biology techniques including molecular cloning
  • Familiarity with microfluidics and single cell analysis platforms


Equal Opportunity Employer Minorities/Women/Veterans/Disabled