Circulating Tumor Cell Analyst
- Employer
- Frederick National Laboratory for Cancer Research
- Location
- Frederick, MD, USA
- Start date
- Jan 9, 2019
View more
- Discipline
- Science/R&D, Oncology
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- BioCapital
Job Details
KEY ROLES/RESPONSIBILITIES
The Research Associate II will:
- Enumerate circulating tumor cells in liquid specimens from cancer patients and from mice harboring patient-derived tumors, and analyze their biomarker patterns, using Amnis imaging flow cytometry and other CTC analysis platforms
- Support monitoring of patient CTC levels on the CellSearch instrument and the Amnis imaging flow cytometer
- Perform in vitro experiments using cell lines to test pharmacodynamic marker responses to novel anti-cancer therapeutics
- Perform a variety of laboratory procedures to characterize marker response
- Assist in the development and validation of novel immunofluorescence assays with guidance from scientific staff
- Support development and implementation of immunofluorescence assays in support of clinical studies and initiatives
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of a Bachelor's degree from an accredited college or university according to the Council for Higher Education Accreditation. Foreign degrees must be evaluated for U.S. equivalency
- Candidate must have completed laboratory science courses in two or more of the following subjects: histology; chemistry; biochemistry; immunology; pharmacology; cell biology; hematology
- In addition to educational requirements, a minimum of five (5) years of related biomedical experience
- Must be able to obtain and maintain a security clearance
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
- Circulating tumor cell detection and quantitation on an established platform, preferably CellSearch or Amnis platform
- Enumeration of circulating tumor cells and analysis of their biomarker patterns in liquid specimens from cancer patients and from mice harboring patient-derived tumors using Amnis imaging flow cytometry
- Experience with in vitro cell line treatments using multiple test agents and drug combinations of interest to determine PD marker feasibility and validation, drug dose responses, timing of marker activation, and characterization of marker responses in the context of various genetic backgrounds. Perform all calculations of drug treatments independently; molarity, experimental reagents, composition, etc.
- Experience with image analysis software
- Experience with GraphPad software
- Experience working in a GLP (or higher) environment, and familiarity with HIPAA/HiTECH regulations
- Quantitative laboratory work in biochemistry, cancer biology, cell biology, biotechnology, and/or histopathology
EXPECTED COMPETENCIES
- Ability to develop, modify methods and techniques independently, under supervision of a lead scientist
- Ability to maintain precise records. Must be able to provide accurate scientific reports including details of experimental procedures, results and conclusions to supervisor
- Ability to be flexible to meet changing needs
- Experience in basic cell biology techniques (antibody-based assays, immunofluorescence assays, cell lysate extraction, protein concentrations, western-blotting, etc.)
- Ability to manage work on multiple projects simultaneously, and to adapt to frequent changes in project priorities
- Ability to quickly master new and novel measurement technologies and instrumentation
- Experience in widefield and fluorescence microscopy
- Excellent written and spoken English language and computer skills (essential)
- Proficiency with Microsoft Office software (Outlook, Excel, Word, and PowerPoint)
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
Company
A rewarding career with global impact
Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.
Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.
We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.
Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.
Discover why joining the Frederick National Laboratory team could be the most important career step you take
- Website
- https://frederick.cancer.gov/
- Phone
- 301-846-1000
- Location
-
8560 Progress Drive
Frederick
MD
21701
US
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