Associate Formulations Scientist - Drug Product Development

Location
92121, San Diego
Posted
Jan 08, 2019
Ref
927488
Required Education
Bachelors Degree
Position Type
Contract

The successful candidate will conduct hands-on laboratory work such as solubility, stability, formulation development for preclinical animal species, solid state characterization, and preliminary salt/polymorph screening to inform the risk in pharmaceutical development of small molecules. Formulation development includes vehicle screening, small scale screening for amorphous solid dispersion and nanosuspensions. Characterization work includes HPLC/MS, XRD, TGA, DSC, and DLS. The scientist will participate in the departmental meeting and present on their work on a regular basis. This is a hands-on, laboratory-based role in a highly collaborative early development environment. 

Job Description: 

  • Provides direct on-site formulation support to enable efficacy, PK, and toxicology studies for San Diego based discovery groups 
  • Conducts drug substance physicochemical characterization of NEC’s to evaluate the risk in development of small molecules 
  • Develop chromatography-based methods for assaying small molecule content, related impurities, and degradation products. Experiences with chiral LC method development is desired. Must have experience with Waters UPLC and Empower software. 
  • Conducts solubilization enhancement studies, and supports enabled formulation development (amorphous solid dispersion, Nano formulation, lipid-based formulation) to improve exposure in the preclinical species 
  • Conduct preliminary salt and polymorph screening 
  • Maintain equipment, interface with equipment vendors and troubleshoot problems when they occur 
  • Interface with Discovery team members to design, schedule and execute experiments. 
  • Strong interpersonal, communication, collaboration and problem-solving skills. 
  • Ability to document work in electronic notebooks, presentations, reports and procedures.

PREREQUISITES: 

  • B.S. or M.S. in Chemistry, Pharmaceutical Sciences, or related scientific discipline. 
  • Must have experiences in the pharmaceutical industry in discovery support, and preformulation. 
  • Advanced degree preferred.