Associate Formulations Scientist - Drug Product Development
The successful candidate will conduct hands-on laboratory work such as solubility, stability, formulation development for preclinical animal species, solid state characterization, and preliminary salt/polymorph screening to inform the risk in pharmaceutical development of small molecules. Formulation development includes vehicle screening, small scale screening for amorphous solid dispersion and nanosuspensions. Characterization work includes HPLC/MS, XRD, TGA, DSC, and DLS. The scientist will participate in the departmental meeting and present on their work on a regular basis. This is a hands-on, laboratory-based role in a highly collaborative early development environment.
- Provides direct on-site formulation support to enable efficacy, PK, and toxicology studies for San Diego based discovery groups
- Conducts drug substance physicochemical characterization of NEC’s to evaluate the risk in development of small molecules
- Develop chromatography-based methods for assaying small molecule content, related impurities, and degradation products. Experiences with chiral LC method development is desired. Must have experience with Waters UPLC and Empower software.
- Conducts solubilization enhancement studies, and supports enabled formulation development (amorphous solid dispersion, Nano formulation, lipid-based formulation) to improve exposure in the preclinical species
- Conduct preliminary salt and polymorph screening
- Maintain equipment, interface with equipment vendors and troubleshoot problems when they occur
- Interface with Discovery team members to design, schedule and execute experiments.
- Strong interpersonal, communication, collaboration and problem-solving skills.
- Ability to document work in electronic notebooks, presentations, reports and procedures.
- B.S. or M.S. in Chemistry, Pharmaceutical Sciences, or related scientific discipline.
- Must have experiences in the pharmaceutical industry in discovery support, and preformulation.
- Advanced degree preferred.