Principal Research Scientist-ADME-Biologics

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Responsibilities

At Lilly, we unite caring with discovery to make life better for people around the world. Due to strategic dedication to the growth of biotechnology, we are seeking an experienced ADME scientist to work in a highly collaborative team environment. Are you looking to grow in your career and contribute at a high level to our strong pipeline of therapies? Can you apply your diverse analytical tools to characterize and optimize factors influencing the absorption, disposition, and pharmacodynamic properties of biologic therapeutics in development as drug entities? The Biotechnology Research/ADME team works closely with toxicology, discovery biology, protein engineering and multiple therapeutic areas as part of a collaborative effort to advance peptides, proteins, and monoclonal antibodies to clinical testing. Lilly offers a unique and dynamic research environment where our teamwork and contributions are valued and recognized. Our patients are waiting. Are you interested in leading key research that will make an impact on the lives of people around the world?

In this role you will be responsible for:

• Oversight of study design and execution for non-clinical PK and PK/PD studies, TK studies.
• Function as a project leader in a multidisciplinary team environment with primary responsibility for the early preclinical development of antibodies and protein molecules.
• Integrate pharmacokinetics and PK/PD with discovery biology to define structure activity relationships guiding protein engineering strategies and optimization of protein therapeutics.
• Interact across groups, including other departments, regulatory agencies, and functional teams within drug disposition.
• Lead preparation of relevant sections of regulatory documents for development and registration of new drugs and line extensions; interact with regulatory agencies worldwide.
• Lead, coach and mentor the technical work of junior scientists.
• Collaborate with scientists in academia.
• Excellent written and oral communication of scientific data, both internally and in the scientific community

45806BR

Basic Qualifications

• Ph.D. in Biochemistry/Biology/Cell Biology or a related discipline in Pharmaceutical Sciences.
• At least 5 years of experience in the development of monoclonal antibodies, peptides/proteins or fusion proteins preferably in industry (Pharma/Biotech).

Additional Skills/Preferences

• Experience with oral protein delivery strategies, development and implementation of animal models for oral peptide delivery.
• Industry (pharma, biotech, CRO, etc.) experience with PK/PD modeling.
• Working knowledge of immunoassay and/or LC/MS bioanalytical methodology.
• Experience with drug development and knowledge of regulatory processes.
• Working in an interdisciplinary team.
• Proven ability to identify scientific issues and tackle problems, both individually and with collaborators in other functional areas.
• Ability to influence, negotiate and communicate with partners in both internal and external organizations.

Additional Information
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.