Scientist, Neuroscience Discovery

Uniquely positioned to enhance quality of life in aging, at Alkahest, we are pioneering science that is rapidly being translated to the clinic. Our approaches utilize in vivo, in vitro, proteomic, and molecular techniques to identify new therapeutics and apply them to patients. 

We are seeking a highly motivated and driven scientist who will be key in establishing and executing in vivo and in vitro assays to advance multiple programs in our therapeutic pipeline. The position focus is primarily on cognition and disorders of the nervous system. The scientist will be responsible for designing in vivo experiments and developing novel assays including behavioral, histological, and biochemical endpoints as well as complementary in vitro experiments utilizing primary cultures and secondary cell lines. The position will lead a team of motivated research associates in carrying out the projects. The role is critical in driving the scientific team in advancing our therapeutic understandings, and will involve establishing, validating, and implementing methodologies in the lab. The role requires dedication, flexibility, excellent communication and organization, and will interact with a team of scientists and research associates to drive multiple projects in parallel. 

We offer a competitive compensation package. 

RESPONSIBILITIES:

• Specific responsibilities include, but are not limited to:   Designing, performing, and analyzing rodent in vivo experiments
• Designing, analyzing, and managing in vitro experiments
• Establishing and optimizing standard and novel behavioral assays
• Administering test agent via multiple routes (IV, PO, IP, SC)
• Performing histology, immunohistochemistry, microscopy, and image analysis
• Biochemical and molecular analysis of cellular lysates (i.e. RT-qPCR, Western blot, ELISA)
• Maintaining familiarity with current scientific literature
• Investigating and developing new methods and technologies for project advancement
• Writing scientific reports
• Managing a team of research associates conducting in vivo and in vitro work
• Interfacing on a regular basis with lead scientific staff to organize, coordinate, schedule, and execute experimental work.

REQUIREMENTS:

• PhD degree from an accredited college/university in a field related to biomedical research, cell biology, molecular biology, biochemistry, or neuroscience; post-doctoral experience preferred
• Minimum of 8 years of progressively advancing academic and/or industry lab experience
• Experience with mouse handling and dosing is necessary
• Experience with behavior and cognitive assays is necessary
• Experience with immunohistochemistry and microscopy is necessary
• Experience with primary neuronal or microglial cell culture is necessary
• Experience with confocal microscopy and image analysis is strongly preferred
• Experience with other biochemical and/or molecular techniques is an advantage
• Ability to work collaboratively and excellent interpersonal, verbal, and written communication skills
• Attention to detail and strong organizational skills