Senior Scientist I, Purification Development

Worcester, MA, US
Dec 18, 2018
Required Education
Bachelors Degree
Position Type
Full time
A Senior Scientist position is available within Purification group in Process Sciences Department at AbbVie Bioresearch Center in Worcester. The group is responsible for developing and supporting downstream manufacturing process for early and late phase clinical biologics programs. We strive for speedy delivery of high quality processes that are high yield with desirable product qualities, cost-effective, manufacturing friendly, and robustness. The group interacts closely with Discovery, Cell Culture Development, Pilot Lab, Protein Analytics, Drug Product Formulation Development, Manufacturing, Quality, and CMC teams. We are seeking an enthusiastic, creative scientist who will make tangible contribution to the continuous improvement and innovation within the organization in delivering innovation therapies to the patients.

Key responsibilities:
  • Develop recovery and purification process that utilizes clarification, chromatography, and membrane filtration technologies for recombinant proteins
  • Design and execute innovative process development and characterization activities, impurity and viral clearance studies
  • Is responsible for technology transfer to scale-up labs and manufacturing facilities, troubleshooting and investigation activities
  • Address and solve technical problems independently, conceive and implement innovative process research ideas, evaluate and integrate state-of-the-art technology to improve manufacturing platform, pursue deep understanding of the process and product, and demonstrate a high level of scientific initiative
  • Author technical report, support and contribute to regulatory filings
  • Provide project update and analysis to cross-functional team and management
  • Present original work internally across departments and at external conferences
  • May author or co-author peer-reviewed scientific papers or patents

  • BS, MS, or PhD degree in chemical engineering or biochemical engineering or related disciplines
  • 10-12+ (BS), 8-10+ (MS), or 0-3+ (PhD) years of experiences in protein purification process development and/or manufacturing support

• Sound scientific understanding of current protein separation technologies and ability to explore and develop new approaches to further advance innovative purification technologies desirable

• Experiences in protein chromatography, membrane filtration, mechanistic and process modeling, a plus
  • Basic knowledge in related functional areas, such as cell culture, protein chemistry and analytics or formulation, a plus
  • Demonstrated record of independent thought, creativity and scientific accomplishment (e.g. peer reviewed journal publications, patents)
  • Candidate must be a goal oriented team player with excellent verbal and written communication skills

Key Leadership Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance

• Learns fast, grasps the "essence" and can change course quickly where indicated

• Raises the bar and is never satisfied with the status quo

• Creates a learning environment, open to suggestions and experimentation for improvement

• Embraces the ideas of others, nurtures innovation and manages innovation to reality

Equal Opportunity Employer Minorities/Women/Veterans/Disabled