Bristol-Myers Squibb Company

Research Investigator, Leads Discovery and Optimization

Location
Hopewell, NJ, US
Posted
Dec 18, 2018
Ref
R1512293
Required Education
Doctorate/PHD/MD
Position Type
Full time
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

As a Research Investigator in Leads Discovery and Optimization at Bristol-Myers Squibb Company, the successful candidate will be trained and skilled in biochemical and cellular assays as it relates to discovery of novel clinical candidates. The successful candidate will have a strong understanding of protein degradation with a proven track record of research in this area. The ideal candidate will be an enthusiastic, self-starter who values attention to detail. An in-depth knowledge in relation to enzyme kinetics, mechanisms of inhibition and enzyme assay platforms is a plus. Responsibilities include, execution of new and established biochemical and cell-based assays, utilization of existing software to analyze data generated and presentation of results. As a member of the organization, the person will be expected to collaborate closely with existing team members as well as actively collaborate with chemists and biologists within relevant therapeutic area teams (oncology, immuno-oncology, immunology, cardiovascular and fibrosis) in order to support and provide insight for an emerging new drug discovery modality. Therefore, strong inter-personal, oral and written communication skills are a must.

Duties/Responsibilities/Qualifications:
  • PhD, plus relevant postdoctoral work and 5+ years of experience in biochemistry and cell biology. Knowledge of targeted protein degradation is a must.
  • Experience with Luminescence/Fluorescence based assays and kinetic and equilibrium binding analyses
  • Design, development and execution of de novo assays to explore mechanism of action and kinetics of compounds. Highly skilled in troubleshooting experimental design and interpret data independently, with the ability to effectively organize, analyze and depict data using common software packages.
  • Ability to learn quickly, present and communicate results, and work closely with others in a team environment