Scientist I, Assay Development (ADC Discovery)

South San Francisco, CA, US
Dec 06, 2018
Required Education
Masters Degree/MBA
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at Stemcentrx, AbbVie's South San Francisco, CA location.

As part of a talented and multi-disciplinary team advancing exciting new approaches to drug discovery and development, AbbVie Stemcentrx is looking for a highly motivated scientist with experience in small molecule and ADC screening. The successful candidate will drive discovery work to understand small molecule potency and how it relates to ADCs. Primary responsibilities will include generation and review of small molecule cytotoxicity and mechanistic data. This position will also contribute to other target and ADC validation activities.

  • Support small molecule screening efforts by independently performing assays to evaluate potency of compounds with diverse mechanisms of action
  • Support efforts to understand potency and mechanism of action of novel small molecules used as warheads on antibody drug conjugates
  • Plan and execute in vitro targeted drug combination studies
  • Implement liquid handling automation into current workflows
  • Work cooperatively with multidisciplinary teams and present results at team meetings
  • Proactively seek out and incorporate novel ideas in line with the group's strategy to better characterize our antibody targets, toxins and ADCs
  • Participate in the drafting of IND and patent documents

  • MS or equivalent education with 3+ years of relevant experience, or BS or equivalent education with 5-6+ years of relevant experience.
  • Experience in assay development, cell biological assays and small molecule screening is required
  • Experience with liquid handling automation, cell imaging systems and flow cytometry highly preferred
  • Prior experience with ADCs and working knowledge of bio-conjugation chemistry a plus.
  • Excellent oral and written communication skills and a proven track record of working effectively in a dynamic, collaborative, team-oriented setting.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled