Research Associate II

Frederick, MD, USA
Dec 05, 2018
Science/R&D, Research
Required Education
Bachelors Degree
Position Type
Full time
The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of state-of-the-art technologies and services that are focused on the design, generation, characterization and application of genetically engineered and biological animal models of human disease, which are aimed at the development of targeted diagnostics and therapies. LASP contributes to advancing human health, developing new treatments, and improving existing treatments for cancer and other diseases while ensuring safe and humane treatment of animals.


The Research Associate II is responsible for:
  • Engage in the validation, characterization, and preclinical evaluation of genetically engineered mouse models for cancer as a critical member of the Center for Advanced Preclinical Research (CAPR) at the Frederick National Laboratory for Cancer Research
  • Will coordinate and perform a variety of experiments aimed at the evaluation of anticancer therapeutics in genetically engineered mouse models as well as allograft models
  • Administer drugs by IP, IV or oral gavage routes
  • Perform complex survival surgeries
  • Perform viral and/or cell injections by multiple routes
  • Monitor animal health status
  • Collect body fluids and tissues
  • Perform tissue culture laboratory work, including maintenance of primary mouse cultures and established cell lines
  • Collect, prepare, and store tissue samples
  • Interface regularly with lead scientific staff to organize, coordinate and schedule experimental work
  • Prepare technical reports, summaries, protocols, quantitative analyses, and maintain appropriate documentation of experiments in Excel and other software
  • Assist CAPR scientists in preparation of data for presentations and reports

  • Possession of a Bachelor's degree from an accredited college or university according to the Council for Higher Education Accreditation (additional qualifying experience may be substituted for the required education); Foreign degrees must be evaluated for U.S. equivalency
  • In addition to the educational requirements, a minimum of five (5) years of related biomedical/research experience
  • Experience in conducting experiments using mouse models, preferably preclinical drug evaluation in tumor models
  • Ability to perform a variety of technical and/or surgical procedures on laboratory animals (rodents), maintain experimental data, and train animal care personnel in specific health observations as needed
  • Ability to keep computer records and maintain data in computer-based applications/databases
  • Complexity of mouse models and drug evaluation studies will require strong organizational skills as well as very detailed and accurate record keeping
  • Knowledge of Standard Operating Procedures for animal facilities, and a basic understanding of maintaining laboratory animals is essential
  • Ability to communicate with project lead researchers in a demanding scientific environment
  • Must be able to obtain and maintain a security clearance

  • Basic laboratory skills (DNA, RNA preparation, tissue culture)
  • Experience with mouse models of cancer and cancer therapeutics, as well as ability to maintain cancer cells in culture.
  • Cancer biology experience preferred but not essential.
  • Previous work with viral or chemical tumor induction methods or surgeries on rodents

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)