Senior Scientist I, Translational Immuno-Oncology

Redwood City, CA, US
Dec 04, 2018
Required Education
Bachelors Degree
Position Type
Full time
The Translational Immuno-Oncology Department is committed to elucidating the mechanisms of our therapeutics as they transition into human clinical studies and equipping them with biomarkers to aid in their progression through the pipeline. We are seeking a highly motivated and collaborative individual with a passion for oncology research, who enjoys working in a fast-paced and dynamic working environment. The successful candidate will work both within the Translational Immuno-Oncology Department and as a member of cross-departmental interdisciplinary teams. They will be expected to design, lead and execute screens for biomarker discovery and validation, analyze and present results and to champion emerging technologies.

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie has expanded its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie in the Redwood City, CA location.

  • Aligned with the overall goals of the team, design and execute creative in vitro and ex vivo experimental workplans, optimize and troubleshoot experimental details, and synthesize and present datasets to extract trends and infer hypotheses
  • Utilize broad technical expertise in cell biology, tumor cell biology, immune cell biology, and in vivo animal models to design in vitro, in vivo, and ex vivo experiments to expand understanding of our therapeutics
  • Establish functional cell-based assays based on readouts including proliferation, differentiation, cytotoxicity, activation, flow cytometry, mRNA expression, etc. with human and rodent cell lines and primary cell cultures
  • Articulate hypotheses, workplans, and results objectively to a variety of audiences in both oral and written communications
  • Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, GxP compliance, and animal care where applicable

  • Senior Scientist I: Bachelor's Degree or equivalent education and typically 10 years of experience, Master's Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary
  • Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions
  • Experience with immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, ELISpot, etc.) primary cell culture, tissue processing, as well as standard molecular biology and biochemical technique
  • Demonstrate excellent ability to utilize all Microsoft Office software, GraphPad Prism, data visualization software, and aptitude and interest to train in other software programs when required for specific instruments
  • Expertise in human immunology, cancer immunotherapy, oncology, cancer cell signaling pathways, and translational research is highly desirable
  • Demonstrated ability to learn, understand and master new experimental techniques.
  • Ability to multitask and work within timelines
  • Demonstrated scientific writing skills and strong verbal communication skills
  • Organize and document data and results in an electronic lab notebook, embrace global registration and inventory systems, utilize shared databases and visualization software to collaborate with all AbbVie Oncology Discovery teams

  • Be versed in the current state of the science of the tumor microenvironment and the interplay between immune cells, stroma and tumor cells
  • Hands-on experience in analysis of complex data sets (RNASeq, Nanostring, high-dimenstional FACS, etc), including use of CYTObank
  • Familiarity with biomarker discovery and translational research

Equal Opportunity Employer Minorities/Women/Veterans/Disabled