Senior Research Investigator, Translational Bioinformatics, Immunoscience and Small Molecule Immuno-
- Employer
- Bristol Myers Squibb Company
- Location
- Princeton, NJ, US
- Start date
- Dec 2, 2018
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- Discipline
- Regulatory, Science/R&D, Bioengineering, Bioinformatics
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Pharm Country, Best Places to Work
Job Details
Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.
We are seeking a highly motivated bioinformatician with industry experience to join our Translational Bioinformatics Immunoscience and Small Molecule Immuno-Oncology team. The successful candidate will help advance Bristol-Myers Squibb's industry leading IMS and IO pipelines through the strategic application of cutting edge bioinformatics approaches. This team interacts with and influences all aspects at BMS from early discovery through development.
Responsibilities:
- Analyze various -omic-scale data including RNA-Seq, Exome and Whole Genome Sequencing, single cell sequencing, high throughput proteomics, and multiplex flow cytometry in order to nominate novel drug targets, enable patient enrichment strategies, and prioritize combination therapies.
- Integrate and mine large-scale external data sets (GEO, TCGA, 1KG, EXAC, Cosmic) to further our understanding of autoimmune diseases and cancer pathogenesis.
- Evaluate and analyze genomics data from clinical trials to understand drug mechanisms and patient response. Extract insights and generate hypotheses to be evaluated in future trials and to inform our discovery pipeline.
- Collaborate with bioinformaticians, statisticians, biologists, biomarker leads, and clinicians to design experiments. Define and implement statistical/computational analysis plans.
Qualifications:
- Ph.D. in bioinformatics, engineering, statistics, physics, molecular biology, genetics, or a similar disciplin
- Five (5) or more years relevant experience in drug discovery research in a pharma or biotech setting.
- Proven track record of independent research under minimal supervision.
- Experience designing complex experiments and statistical analysis plans.
- Strong background in -omic (DNA, RNA, epigenetic, proteomic) data analysis and biological interpretation.
- Experience working with data from clinical trials.
- Solid background in Immunoscience and/or Immuno-Oncology biology
- Ability to communicate effectively with biologists, biostatisticians and computational scientists.
- Proficiency using R and Bioconductor packages, at least one scripting language (Python, Perl), and SQL.
- Experience working with Linux high performance compute clusters and cloud based computing platforms (Amazon EC2).
- Working knowledge of commercial and publicly available biological databases including NCBI, Ensembl, ArrayExpress/GEO, SRA, TCGA and 1000 Genomes is expected.
- Fluency in NGS experiments and data analysis (e.g. GATK, Cufflinks, SAMtools, BAMtools etc.) is preferred.
Company
Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.
At Bristol Myers Squibb, we believe in the power of science to address some of the most challenging diseases of our time. Our focus on these unmet needs comes during a remarkable time, when unprecedented scientific breakthroughs are advancing the treatment of disease as never before in human history.
We work every day to transform patients’ lives through science. Each day, our employees around the world work together for patients – they are at the center of everything we do. They inspire us. They are the reason we come to work each day.
We combine the agility of a biotech with the reach and resources of an established pharmaceutical company to create a global leading biopharma company powered by talented individuals who drive scientific innovation.
- Website
- http://www.bms.com/
- Phone
- +1-800-332-2056
- Location
-
430 E. 29th St
14th Floor
New York
New York
10016
United States
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