Associate Manager, Neuroscience & Ophthalmology Genetics

Location
Tarrytown, New York, US
Posted
Dec 02, 2018
Ref
14884BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
The Regeneron Genetics Center RGC is a wholly-owned subsidiary of the Company, whose goals are to apply large scale human genetics to identify new drug targets and to guide the development of therapeutics programs and precision medicine. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the RGC specializes in ultra-high-throughput exome sequencing, large scale informatics and data analysis encompassing genomics and electronic health records, and translating genetic discoveries into new biology and drug discovery opportunities. The RGC leverages multiple approaches including large population based studies, Mendelian genetics and family based studies, founder population genetics, and large-scale disease focused projects and has developed a network of over 50 collaborations with research organizations around the world. Including some of the largest sequencing studies in the world, such as the DiscovEHR study in collaboration with Geisinger Health System, and an initiative to sequence 500,000 participants with the UK Biobank, the RGC has built one of the largest human genetics databases, including sequence data from over several hundred thousand participants and rapidly growing. Our interests encompass a breadth of different areas across all therapeutic areas and the RGC is highly integrated into all facets of research and development at Regeneron. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and providers of collaborating health-care systems, improving patient outcomes, and identifying novel targets for drug development . Summary. We are looking for a scientist in our Neuroscience & Ophthalmology Therapeutic Area Genetics team. The position will take on responsibilities for the design, execution, and interpretation of genetics studies focusing on neurological diseases, as part of the Therapeutic Area Genetics team, and in collaboration with the Analytical Genetics team and the genome sequencing and informatics production teams. Primary responsibilities will be to lead genetics discovery projects, support new programs/collaborations, and to support the execution of overall scientific strategy in neurological disease genetics. Goals of the team will be to apply genetics to target discovery, selecting indications for drug programs, and patient/disease stratification through genetic analyses . Responsibilities - Work with a multidisciplinary genetics team consisting of human genetics scientists, bioinformaticians, statistical geneticists, and other required staff to design, execute, and interpret genetics studies related to neurological diseases for the Center. Collaborate with external partners and internal Regeneron scientists in such efforts - Work with research and clinical colleagues at Regeneron to introduce human genetics evidence and studies into current research plans and to support drug development efforts - Provide human genetics expertise and consult on projects within other R&D departments at Regeneron including therapeutic focus area teams in Neuroscience, precision medicine, and early and late clinical development - Survey the literature and conferences for discoveries and findings from the broader genetics community. Integrate such findings into study opportunities and considerations internally - Communicate and report study findings and analyses with leadership, administration, and collaborators . Requirements. This position requires a PhD with at least 3 years of experience in human genetics research and a translational genetics focus. Additional requirements include - A preference for prior experience in neurogenetics studies - Demonstrated ability to design and lead human genetics studies delivering novel genetic findings and medically relevant gene discoveries in a team-based environment - Familiarity with statistical genetics and experience leading a breadth of study designs and analyses spanning family and Mendelian studies, population genotype-phenotype association studies, etc - Involvement in or use of large-scale WES/WGS data sets such as GO-ESP, 1,000 Genomes Project, CHARGE consortium, Centers for Mendelian Genomics, ExAC, etc - Experience with multiple platforms chip-based genotyping, WES & WGS, Sanger, custom capture targeted sequencing, etc as well as other genomic profiling technologies microarrays, RNASeq, etc - Preferred . experience with genetic analyses involving complex loci e.g. HLA, 17q21. 31 and relevant methods and tools - Experience with molecular characterization and functional studies geared towards elucidating gene functions and the mechanistic basis for genetic associations - Familiarity with clinical genetics and various genetic models of disease - Motivated team player with a desire to pursue genetic discovery in a deadline-oriented, multi-disciplinary environment . This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business . To all agencies . Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid . Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.