Senior Scientist II/ III, Translational Immunology

Worcester, MA, US
Nov 29, 2018
Required Education
Bachelors Degree
Position Type
Full time
The Translational Immunology Department is committed to elucidating the mechanisms of our therapeutics as they transition into human clinical studies and equipping them with biomarkers to aid in their progression through the pipeline.

The Senior Scientist will be responsible for developing translational research strategies to support the advancement of multiple therapeutics for the treatment of immunologically mediated diseases, including Rheumatoid Arthritis, Crohn's Disease, Psoriasis, Systemic Lupus Erythematosus, and Spondylosing Arthritis. The successful candidate will be responsible for identifying and developing biomarker assays that can be deployed in early clinical trials to measure drug pharmacodynamics and disease related changes. The successful candidate will have a strong expertise in immunology, as well as a demonstrated understanding of clinical biomarker assay feasibility and development with varied techniques, including flow cytometry, ELISA, cell based assays, and molecular approaches. The successful candidate will be part of the leadership team of the department that will include building collaborations across functional areas with key partners, building and executing collaborations with external partners, and representing program related work to senior management audiences. Excellent written and verbal communication is required.

The successful candidate will partner with both clinical colleagues and project development teams to implement these assays into clinical trials in order to generate experimental data and address biological questions for our development candidates. Critical evaluation of the clinical biomarker data generated to drive decision making for development programs will also be required.

In addition, the successful candidate may contribute to academic collaborations that will advance our understanding of the mechanism of diseases of interest and their relationship to our assets.

Job Responsibilities:

  • Develop biomarker strategies for projects emerging from the Discovery pipeline.
  • Work effectively with a team in a matrix environment including Discovery, Clinical, Drug Metabolism & Pharmacokinetics, and Pharmacogenomics to build a shared work plan and ensure alignment between stakeholders.
  • Effectively communicate in writing and orally the biomarker strategy and data packages to varied audiences.
  • Demonstrate the ability to resolve key project hurdles and assumptions by effectively utilizing available information and technical expertise.
  • Publish research in peer-reviewed journals and present work at scientific conferences.
  • Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program opportunities to pursue project relevant leads that are in line with the group's strategy.
  • Maintain a high level of productivity in the laboratory.
  • Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds.
  • May mentor/supervise a team of one or more and guide and evaluate the performance of those individuals; is accountable for the effective performance of the team/individuals.

  • Bachelor's Degree or equivalent education and typically 12-14+ years of experience, Master's Degree or equivalent education and typically 10-12+ years of experience, PhD and typically 4-6+ years of experience.
  • Effective writer and communicator of research or other regulatory materials.
  • Possess demonstrated expertise in immunology related to human autoimmune and inflammatory diseases. Individuals with expertise in inflammatory bowel disease are particularly encouraged to apply.

Key AbbVie Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
  • Learns, fast, grasps the 'essence' and can change the course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled