Associate Scientist, Neuroinflammation

Cambridge, MA, US
Nov 29, 2018
Required Education
Bachelors Degree
Position Type
Full time
AbbVie has invested in a new research enterprise in Cambridge, Boston - the Foundational Neuroscience Center (FNC). The FNC investigates the fundamental biological mechanisms underpinning neurodegenerative disease with particular attention to Alzheimer's disease (AD). Pre-clinical, genetic, and bioinformatics studies implicate neuroinflammatory processes as likely contributing factors to Alzheimer's disease onset and progression. Our discovery research team aims to understand how microglia, the predominant innate immune cell type in the CNS, may be therapeutically modulated to improve clinical outcomes in this disease.

We are seeking an Associate Scientist preferably with a pharma/biotech background to join the Neuroinflammation group at the FNC. This individual, with a background in neuroscience and/or immunology, and technical experience in molecular and cell biology, will be responsible for supporting early drug discovery efforts to identify and validate novel drug targets, including novel assay development and validation, and characterization of model systems to study neuroinflammation and investigate the basic biology behind microglial dysfunction in AD.

Key Responsibilities:

  • Plan and execute experiments - collect, analyze, interpret and share data
  • Contribute technical and scientific expertise to neuroinflammation project teams
  • Generate robust and complete data sets to support key Go/NoGo decisions on novel drug targets
  • Read and apply relevant scientific literature
  • Become expert with novel technologies and laboratory techniques
  • Lead and/or assist in writing and revising SOPs
  • Work diligently and efficiently to meet deadlines in a fast-paced environment
  • Adhere to safety and compliance
  • Participate and/or present in internal meetings

Position will be hired based on level of experience.

  • Bachelor's Degree in biology or related field with 0-3+ years, or Master's Degree with 0+ years of relevant laboratory experience
  • Demonstrated ability to independently design, execute, interpret and troubleshoot critical experiments to answer scientific questions
  • Proficiency with cellular analytical techniques such as flow cytometry, immunohistochemistry, immunofluorescence microscopy, and tissue laser capture
  • Experience and/or willingness to work with live rodents and human brain tissue
  • Aptitude for basic statistics and software packages such as GraphPad Prism
  • Demonstrated ability to work well in a collaborative team-oriented environment
  • Demonstrated ability to learn, understand and master new experimental techniques
  • Strong organizational skills that enable multitasking and working within timelines
  • Demonstrated scientific writing skills, record keeping and strong verbal communication skills

Preferred Qualifications:

  • Pharmaceutical and/or biotech industry experience
  • Experience with acute cell isolation from rodent or human brain
  • Proficiency with sterile cell culture techniques

Equal Opportunity Employer Minorities/Women/Veterans/Disabled