Scientist I, Biological NMR_Spectroscopist/Biophysicist

Location
Bethesda, Maryland, United States
Posted
Nov 28, 2018
Ref
106
Hotbed
BioCapital
Required Education
Doctorate/PHD/MD
Position Type
Full time
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

KEY ROLES/RESPONSIBILITIES

Scientist I - Biological NMR Spectroscopist/Biophysicist
  • Work in a fast-paced environment, providing NMR and biophysics support to the FNL/NCI RAS Initiative
  • Work closely with a highly collaborative multidisciplinary team of chemists, biochemists, structural and cell biologists, to discover, develop, and optimize pharmaceutical agents for use as RAS inhibitors
  • Design and conduct NMR experiments, collect and analyze data
  • Solve NMR structures of RAS protein in complexes with relevant small molecule inhibitors
  • Provide biophysics support for drug/protein interaction analysis
  • Work independently, however within highly collaborative team environment
  • Stay informed of the latest findings in cancer drug discovery and structural biology

BASIC QUALIFICATIONS
  • Possession of a doctorate degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education).
  • No experience required beyond the doctorate degree
  • Working knowledge of multidimensional heteronuclear NMR experiments for elucidation of protein structure
  • Strong background in NMR spectroscopy
  • Expertise in protein NMR, including analysis of protein-drug interactions, protein complexes, and proteins on membrane/membrane mimetics
  • Experience with SPR, ITC, and other biophysical techniques to measure protein-drug interaction
  • Must be able to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS
  • At least 2 years of post-doctoral experience in protein NMR
  • Experience with RAS family proteins NMR
  • Experience with NMR analysis of RAS proteins interacting with effectors/binding partners
  • Must be highly collaborative, with excellent communication skills, self-motivated, and team-oriented
  • Able to balance workload over multiple projects
  • Excellent communication skills
  • Works well within a multidisciplinary team of chemists, biochemists, biologists, and computational chemists