Facilities Manager

94080, South San Francisco
Nov 27, 2018
Required Education
Bachelors Degree
Position Type
Full time

About Principia Biopharma

Principia Biopharma is a clinical-stage biopharmaceutical company dedicated to bringing transformative oral therapies to patients with significant unmet medical needs in immunology and oncology. Principia’s proprietary Tailored Covalency® platform enables the Company to design and develop reversible and irreversible covalent, small molecule inhibitors with potencies and selectivities that have the potential to rival those of injectable biologics, yet maintain the convenience of a pill. PRN1008, a reversible covalent BTK inhibitor, is being evaluated in a Phase 2 clinical trial in patients with pemphigus, an orphan autoimmune disease, and in a Phase 2 clinical trial in patients with immune thrombocytopenic purpura, a rare hematological disease.  PRN2246, a low dose covalent BTK inhibitor which crosses the blood-brain barrier, is being developed for multiple sclerosis and, potentially, for other diseases of the central nervous system.  It has completed dosing in a Phase 1 clinical trial in healthy volunteers and has been partnered to Sanofi. PRN1371, a covalent inhibitor of Fibroblast Growth Factor Receptor, or FGFR, is being evaluated in a Phase 1 trial in patients with solid tumors.


Principia Biopharma is looking for a Facilities Manager who will be responsible for overseeing the physical security, maintenance, and operations of Principia's facilities, building systems, laboratory equipment and custodial services. The successful candidate will assist with the planning and execution of building construction or renovation projects, manage leases, contractors and budgets related to buildings and facilities.  Additionally, the facilities manager will ensure that facilities and equipment for all functional areas operate with the highest level of safety and operational efficiency.  Under minimal supervision, the Facilities Manager will provide day-to-day oversight of the utility and laboratory equipment and work closely with the Research & Development staff to manage and oversee Integrated Facilities Management IFM service maintenance and repair coverage. 

Functional areas include process development, tissue culture labs, facilities, office and meeting space, and warehousing.  To support the ongoing research and production that will be conducted at this site, the Facilities Manager will oversee several crucial facets of building operations, including, but not limited to, maintenance, monitoring systems, compliance, and planning. 

PRIMARY RESPONSIBILITIES include the following:  

Plans work schedule to maintain safe, clean, and healthy conditions on company property to achieve the best working environment possible for employees and visitors. 

Responsible for addressing and handling all facilities requests from internal colleagues, e.g. electricity/power, lighting, door, lock, HVAC, kitchen appliances, copiers, fax machines, printers and other related issues. 

Direct and carry out all office furniture and equipment move including, but not limited to, desks, keyboard trays, monitor arms, pictures, signage, etc. 

Coordinate with vendors to ensure preventative maintenance for office and server room systems including. HVAC, fire suppression, back-up power, electrical, mechanical, & security systems as well as other related building systems. 

Must be willing to serve as the primary lab emergency contact and safety coordinator, ensure and enforce. compliance with safety standards among all members of the lab. 

Develop and adhere to operations & capital improvement budgets. 

Manage office space layout and allocation of space; plan & manage future facilities expansion. 

Coordinate all facility and office equipment repairs, modifications and maintenance with  

       vendors including ordering of furniture and handling any issues relating to the operations of the office. 

Manage and coordinate recycling & document destruction services. 

Manage and oversee cleaning staff and ensure cleanliness of office space including offices, conference rooms, lavatories, recycling and kitchen areas. Coordinate and convey any changes or special requirements with cleaning vendors. 

Develops long and short-range maintenance plans/programs (e.g. emergency response plans, energy management plans, annual budget, etc.) for the purpose of ensuring that district resources are effectively utilized. 

Inspects new construction, repair work, projects, equipment, work orders, daily maintenance and supplies for the purpose of ensuring that jobs are completed efficiently; specifications for major capital improvements are within local/state/federal regulations; and approving inspection reports and payment requests. 

Solves complex regulatory, mechanical, electrical, and electronic issues/questions. 

Represents site Facility Operations organization at all internal and external audits. 

Ensures equipment availability is adequate to meet the organization's requirements. Central plant services (Chilled Water, Heating Hot Water, DI Water). HVAC air distribution and management, Building Management System, Standby Generator, support equipment. Chillers, boilers, air handlers, exhaust fans, pumps, sensors, fan coils, emergency generator, air compressors, vacuum pumps, DI water plant, building controls, setting and schedules. Optimize energy. 

Develop and conduct emergency drills such as fire, earthquake testing and training sessions for employees including disaster preparedness programs. 

Promote and coordinate specific activities within the emergency services program; prepare program event and facility marketing materials including news releases, flyers, schedules of events, pamphlets and brochures. 

Perform a variety of facilities-related functions supporting the Environmental Health and Safety team 

Other duties may be assigned. 

This job has no supervisory responsibilities. 


This job requires a combination of analytical, organizational and interpersonal skills.  To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. 


BS degree with 6+ years of pharmaceutical facilities experience and 3+ years of supervisory experience. 

Experience overseeing lab safety and adherence to regulatory guidelines, and background in managing a hazardous waste program are strongly preferred. 

Strong facility-related (e.g. mechanical, electrical) assessment and troubleshooting skills. 

Desire to work in a fast-paced, team-centric environment a requirement. 

Great organizational and communication skills – written and verbal – and attention to detail are a must. 

Certified Facility Manager (CFM) preferred. 

GMP experience and safety knowledge understanding of OSHA requirements. 

Frequent to continuously lifting or moving materials that are 1 to 40 lbs. 

Frequent standing, sitting, and walking. 

Ability to use power and hand tools and operate a motor vehicle. 

Demonstrated ability to negotiate with various vendors on behalf of the Company. 

Excellent verbal and written communication skills. 

Demonstrated customer service, communication and organizational skills. 

Strong troubleshooting skills. 

Proven ability to creatively problem-solve. 


The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. 

 Principia Biopharma, inc. is an equal opportunity employer.