Scientist/Sr. Scientist: In Vivo Pharmacology

94043, Mountain View
Nov 26, 2018
Required Education
Position Type
Full time

Amunix Operating Inc., a development stage biotech company located in Mountain View, CA, is seeking an experienced, hands-on Scientist/Senior Scientist to provide pharmacology and toxicology expertise for the development of immuno-oncology therapeutics.  The successful candidate will be responsible for designing and overseeing the execution of mechanistic-based in-vivo studies through ex-vivo analysis that evaluate the efficacy and safety of drug candidates, including pivotal studies to enable first-in-human clinical trials.  He/She is expected to deliver a balanced assessment of the risk/benefit profile associated with drug candidates.  The individual must have a strong pharmacology background in cancer immunology, able to work collaboratively with internal cross-functional teams and external CROs and consultants to deliver quality and timely findings in support of drug candidate advancement.  The candidate must have a strong desire and ability to work in a fast paced, team-oriented, dynamic environment. 

Essential duties and responsibilities include the following: 

• Design, implement and oversee efficacy/MOA/PK/biodistribution studies in support of preclinical immuno-oncology programs.  Disease-relevant in vivo models including syngeneic, xenografts, genetically engineered and humanized mouse models, and patient-derived xenografts (PDX)

• Design, implement and manage toxicity studies in NHP

• Perform ex vivo studies for pharmacological characterization of drug candidates 

• Critical scientific/technical data analysis and interpretation in support immuno-oncology drug discovery and development  

• Work both independently and collaboratively with other R&D members in a multi-disciplinary team setting

• Effectively communicate scientific concepts, findings and interpretation to multi-disciplinary teams

• Other duties may be assigned