Scientist I, NGS Core

Frederick, MD, USA
Nov 22, 2018
Required Education
Position Type
Full time
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI's intramural Center for Cancer Research (CCR). The dedicated units provide electron microscopy, protein characterization, protein expression, optical microscopy and genetics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR). CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.



  • Assists with Next Generation (NGS) Sequencing for the core facility. Current platforms include the Illumina NovaSeq, HiSeq, NextSeq, MiSeq, 10XGenomics, PacBio, Nanopore, Bionano and additional platforms in the future. Projects are highly specialized and require technical proficiency, problem solving skills and good judgment.
  • Works with SF Research & Development group, director, group leaders and informatics staff to develop, implement and perform laboratory processes in support of the SF operations, especially for development in the field of long read technology.
  • Assists in the identification, research, optimization and implementation of new processes or technologies that serve to introduce new applications, or improve data quality or efficiency of production pipelines, especially with a focus on long read sequencing applications.
  • Coordinates with SF, quality management and informatics personnel to implement updates to equipment, chemistry and processes.
  • Remains current with new applications and technologies associated with NGS sample preparation, library construction, sample enrichment and target capture.

  • Possession of a Doctoral degree (qualifying experience may be substituted for required education). Foreign degrees must be evaluated for U.S. equivalency.
  • Extensive experience in molecular biology or genetics/genomics, isolation and manipulation of DNA and RNA, experience with high throughput platforms, applications and technology
  • Demonstrated ability for independent design and performance of experiments, troubleshooting, and ability to develop/optimize new assays or production methods under the direction of a lab supervisor or scientist.
  • Proficiency in MS Excel, Word and PowerPoint
  • Must be able to obtain and maintain a security clearance

  • Experience working within a core/service facility
  • Experience with Illumina (Solexa), Pacbio or other NGS sequencing platforms, sequencer operation and maintenance is highly desired. Work in a core/service facility a plus.
  • Experience with next gen sequencing development, troubleshooting, analysis, and laboratory automation.
  • Ability to work independently or on a team, adapt to changing task priorities, and able to train other personnel in techniques with proficiency.
  • Experience with Illumina, PacBio or other NGS sequencing platforms, generation of libraries
  • Experience with next-generation sequencing development, troubleshooting, analysis, and laboratory automation
  • Familiarity with usage of a LIMS
  • Good oral and written communication skills, and proficient organizational and time management capabilities.

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)