Sr. Assoc Scientist, Immuno-Oncology

Employer
Celgene
Location
Seattle, WA, US
Posted
Nov 21, 2018
Ref
1803621
Required Education
Bachelors Degree
Position Type
Full time
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

The candidate will work with the Immuno-Oncology team by contributing to biomarker development and translational medicine correlative studies. The successful candidate will be responsible for contributing to translational development strategies and execution for Celgene's drugs from Phase I through approval. Expertise in developing and qualifying biomarkers for clinical trials, and strong knowledge in immunology and tumor biology is required. The individual will work with contract research organizations as well as internal and external collaborators. Activities include biomarker identification, generation and analysis of data that supports patient stratification and the pharmacodynamic evaluation of drugs in the clinical setting. Candidate will additionally support clinical study start-up and monitoring of translational development endpoints. Candidates with an understanding of, and experience with, regulatory activities encouraged.
Responsibilities:
  • Actively participate in the development of immune cell assays for drug candidate evaluation, mechanistic studies, and biomarker development
  • Evaluate innovative technologies for developing biomarker assays
  • Assist in the coordination of external collaborations contract research laboratories
  • Drive transfer of biomarker assays to contract research organizations to the appropriate level of validation/qualification
  • Perform a wide range of assigned research experiments with efficiency, accuracy and attention to detail, conduct analysis and report results
  • Independently follow protocols and/or procedures and function with minimal supervision
  • Contribute to design of experimental procedures and search literature for targeted information
  • Interact with manager and project team to review data and plan next steps
  • Represent translational development on clinical and cross-functional study teams
  • Participate in regulatory submission activities
Specific Duties:
  • Execute, under supervisor's direction, the development of in-vitro and ex-vivo assays to translate preclinical data into clinical biomarkers for advancing drug candidates through clinical trials
  • Contribute to and help coordinate collaborative efforts, both internally and externally
  • Generate, analyze, and report experimental results
  • Participate in Immuno-oncology team meetings to present data and provide analysis
  • Maintain familiarity with current techniques and procedures
  • Assist with the evaluation of innovative technologies directly related to Immuno-oncology biomarker development
  • Contribute to the writing of non-clinical pharmacology study reports, invention disclosures, and contribute to the writing of investigator brochures, IND applications, regulatory annual reports, and other regulatory documents when appropriate
Qualifications:
  • B.S. or M.S. degree in life sciences or medical sciences field with at least 8 years of successful experience as a research associate and at bench in an industrial setting
  • Solid understanding of scientific mechanisms and experimental techniques, with knowledge of immunology and cancer cell biology preferable
  • Experience working with and managing CROs
  • Familiarity with techniques related to biomarker research and development
  • Relevant skills include proficiency in immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, ELISpot, etc.)
  • Familiarity with and experience in the drug development process from IND filing through BLA/MAA filing in an industry setting
  • Experience with clinical assay validation (Flow cytometry, PCR, soluble factor)
  • Ability to multitask, independently organize time, and plan specifics of work
  • Excellent communication and interpersonal skills demonstrated in a team environment
  • Familiarity with data management tools and software for analyzing translational data sets from various assay formats. Biological interpretation of high content data sets in collaboration with computational biology
  • Detail-oriented with the ability to identify and implement creative solutions


Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.