Senior Scientist I, Assay Development (ADC Discovery)

South San Francisco, CA, US
Nov 21, 2018
Required Education
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at Stemcentrx, AbbVie's South San Francisco, CA location.


Senior Scientist I - ADC Discovery/Assay Development

As part of a talented and multi-disciplinary team advancing exciting new approaches to drug discovery and development, AbbVie Stemcentrx is looking for a highly motivated scientist with experience in small molecule and ADC screening and development. The successful candidate will drive discovery work to understand small molecule potency and how it relates to ADCs. Responsibilities will include generation and review of small molecule cytotoxicity and mechanistic data, coupled with analysis of subsequent ADC data to identify ideal characteristics for ADC warheads.


  • Lead efforts to understand potency and mechanism of action of novel small molecules used as warheads on antibody drug conjugates
  • Work cooperatively with multidisciplinary team to present results and guide strategy
  • Support small molecule (low/medium throughput) screening efforts by independently performing assays to evaluate potency of compounds with diverse mechanisms of action
  • Develop biochemical assays to measure compound activity
  • Plan and execute in vitro targeted drug combination studies
  • Identify trends between ADCs and corresponding small molecules
  • May include cell imaging and ADC internalization and trafficking studies
  • Proactively seek out and incorporate novel ideas in line with the group's strategy to better characterize our antibody targets, toxins and ADCs
  • Draft IND and patent documents and occasionally present at scientific conferences and symposiums


  • Ph.D in a relevant area, or MS or equivalent education with 8+ of experience, or BS or equivalent education with 10+ years of experience.
  • Experience in small molecule screening, preferrably in ADCs, is required.
  • Highly motivated, goal oriented and independent scientist with proven technical expertise in small molecule screening (cell and biochemical assay formats).
  • Prior experience with ADCs and working knowledge of bio-conjugation chemistry a plus.
  • Experience with cell imaging systems and flow-cytometry a plus.
  • Proven management skills with track record of direct reports or guiding and teaching scientific staff.
  • Excellent oral and written communication skills and a proven track record of working effectively in a dynamic, collaborative, team-oriented setting.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled