Bristol-Myers Squibb Company

Principal Scientist, Translational Bioinformatics

Location
Cambridge, MA, US
Posted
Nov 20, 2018
Ref
R1509905
Required Education
Doctorate/PHD/MD
Position Type
Full time
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

We are seeking highly experienced bioinformaticians to join the bioinformatics analysis team at our new site in Cambridge, MA. You will use cutting-edge bioinformatic approaches to integrate and analyze genomic datasets from preclinical studies, clinical samples, and real-world datasets to identify mechanisms of resistance to current oncology and immuno-oncology therapies. You will collaborate with experts in oncology and drug discovery inside and outside of BMS to advance our understanding of resistance to current therapies and develop new approaches to benefit patients.

Responsibilities
  • Engage experimental biologists, clinicians and other key stakeholders to develop and execute data analysis strategies for pre-clinical and clinical studies
  • Analyze pre-clinical and clinical datasets (e.g., large-scale omics datasets including RNASeq, exome and whole genome sequencing, single cell sequencing) to generate actionable insights
  • Identify potential biomarkers for patient enrichment strategies and gain mechanistic insights of responses and resistances to I-O treatments
  • Summarize analysis results and report conclusions to BMS decision-making bodies and to the external scientific community
  • Evaluate and adapt latest scientific findings and methods into bioinformatics analysis plans
  • Serve as a subject-matter expert and provide bioinformatics guidance in cross functional teams
  • Manage alliances and external collaborations

Qualifications:
  • Ph.D. in bioinformatics, statistics, biological or physical science with 10+ years of industry experience
  • Demonstrated experience working with clinical study data is required; familiar with late stage clinical development process
  • Deep understanding of disease biology in immune-oncology is a strong plus
  • Ability to work both independently and collaboratively, and to handle several concurrent, fast-paced projects while conforming with rigorous requirements of clinical studies
  • Broad experience with data generated by one or more high-throughput molecular assays: next-generation sequencing, flow cytometry, mass spectrometry proteomics, etc.
  • Strong experience using high-level programming languages such as R, MATLAB, Python or Perl for complex data analysis and reproducible research practices
  • Strong problem-solving and collaboration skills, as well as rigorous and creative thinking
  • Excellent communication, data presentation and visualization skills
  • Capable of establishing strong working relationships across the organization
  • Strong publication record