Associate Scientist II/Scientist I, Research Pharmacology

South San Francisco, CA, US
Nov 18, 2018
Required Education
Bachelors Degree
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at Stemcentrx, AbbVie's South San Francisco, CA location.

The Research Pharmacology Department is searching for a Scientist I who will participate in evaluating novel anti-cancer therapies for pharmacokinetics (PK), and biomarker analyses in vivo . The candidate will measure drug concentrations and/or biomarkers to be used for PK study analyses; optimize ligand binding assay protocols as needed; perform non-compartmental pharmacokinetics analyses and interpret data; and, communicate data via presentations and reports. The candidate will spend a mixture of their time in the lab environment and performing computer work and analysis. Opportunities for additional projects related to pharmacokinetics and/or pharmacodynamics could be granted based on candidate's interests. The ability to work independently and efficiently on multiple responsibilities, and effectively participate and communicate as part of team, is a prerequisite.

Key Responsibilities
  • Therapeutic or biomarker concentration assessment (ELISA/MSD) in rodent blood samples and ligand binding assay development
  • Analysis of ELISA/MSD assay data
  • Non-compartmental pharmacokinetics analysis with Phoenix WinNonlin software
  • Data presentation and reports

  • BS/MS in Molecular & Cell Biology, Biochemistry, Engineering, or a related discipline, with 5+ (BS) or 2+ (MS) years of relevant research experience
  • Hands-on experience with ELISA/MSD and other Bioassays required
  • Hands-on experience with pharmacokinetics analyses desired
  • Strong written and verbal communication skills
  • Organized, detailed and disciplined record keeping is required

Character Requirements:
  • Flexibility and motivation to learn techniques and accomplish goals outside those stated above
  • Ability to manage multiple responsibilities and meet deadlines in a fast-paced environment
  • Entrepreneurial personality, with problem solving skills, critical thinking ability, and excellent communication skills
  • Highly motivated and independent with an ability to adapt to changing priorities in a fast-paced environment
  • Raises the bar and is never satisfied with the status quo
  • Excited to participate in and contribute to company culture

Posting Grade: 15

Equal Opportunity Employer Minorities/Women/Veterans/Disabled