Scientist/Senior Scientist, New Technologies

94080, South San Francisco
Nov 16, 2018
Required Education
Position Type
Full time

Harpoon Therapeutics is a clinical-stage biotech company located in South San Francisco. The company is developing biologics with novel molecular formats to engage and activate immune cells for the treatment of cancer and other diseases. The New Technology Group at Harpoon is focused on the development of novel conditionally active biologic prodrugs that is preferentially active in the tumor or other disease microenvironments and enable the safe targeting of previously intractable therapeutic targets. We are currently seeking a Scientist/Sr. Scientist in our group to advance therapeutic candidates through preclinical proof-of-concept, propose development strategies, and help establish a pipeline of conditionally active biologic prodrugs.


- Conceive, design, and perform preclinical proof-of-concept experiments, in vitro and in vivo, to help build a pipeline of novel protease-activated biologic prodrugs

- Collaborate with other internal research and development functional groups and direct the work of Research Associates as necessary

- Help manage work with external CROs, including bioanalytical assay development as well as nonclinical pharmacology and toxicology studies

- Prepare and present data at internal and external meetings, keep accurate and update-to-date records, assist with legal (IP) and regulatory (IND) filings


- PhD in immunology or a related discipline required, with 1-4 years of postdoctoral experience preferred

- Knowledge of immunology concepts, either pertaining to immune-oncology or pathologies underlying autoimmune/inflammatory diseases

- Experience with isolating primary immune cells and characterizing cell subsets with functional immune cell assays and multi-color flow cytometry

- Experience with in vivo mouse model development and characterization

- Rigorous and meticulous experimentalist

- Effective communication and organization skills