Bristol-Myers Squibb Company

Associate Director

Location
Waltham, MA
Posted
Nov 16, 2018
Ref
R1511271
Required Education
Doctorate/PHD/MD
Position Type
Full time
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

We are seeking a highly motivated and innovative leader who will build and lead a laboratory group, located in Cambridge, Boston to develop and transfer high throughput assays for hit identification, hit triage and Lead optimization. The group will work in close proximity to Oncology Biology, Translational Medicine, and Molecular Discovery Technology at Cambridge with a mission to discover and develop innovative Immuno-oncology and Oncology pipelines. This leader will be a member of the portfolio governance team, and will be expected to represent Leads Discovery and Optimization (LDO) capabilities to the local project teams as well as manage the portfolio needs. The successful candidate will join LDO leadership team and have a direct reporting relationship with the Vice President of LDO.

The successful candidate will have:

(a) knowledge and demonstrated a track record to develop and validate high throughput assays (biochemical, cellular, biophysical, other) on cost effective and up-to-date technical platforms,

(b) a good understanding of cell signaling in cancer biology and immunology,

(c) broad experiences in assay trouble shooting and exploration of new technology platforms to enhance the infrastructure for discovery program support,

(d) ability to manage across projects across functional lines and geographic sites/locations,

(e) identify and/or innovate new technologies or functional line projects that bring value and efficiency to BMS,

(f) represent technical and scientific ideas, as well as project progress/updates to preclinical research teams, IORB portfolio governance, LDO colleagues and leadership/governance,

(g) contribute to the development of clinical assays derived from preclinical flowchart assays and contribute to the development of regulatory documents (IND, IB, etc),

(h) strong collaborative and written/verbal communication skills and a positive attitude to interact with multiple stakeholders (e.g. therapeutic area teams, Chemistry and Biology leads and outside vendors), and

(i) scientific leadership both at the bench and at data analysis.

Qualifications:
  • PH. D with minimal 8 years of scientific experience in immunology or tumor oncology.
  • Comprehensive technical expertise in developing and performing diverse in vitro immunoassays with whole blood, T-cells, B-cells, monocytes and macrophages.
  • Hands-on experience with phenotypic screens
  • Hands-on experience with confocal imaging, flow, HTRF, qPCR, and cell based assays
  • Hands on knowledge of contemporary automated platforms used for hit identification and lead optimization instrumentation would be very valuable.
  • Proficiency in designing 384 and 1536 well assays and adept with robotics and lab automation
  • Broad knowledge in compound screening strategy is critical
  • Technology development and implementation experience will be very useful
  • Work with cross-functional project teams to implement automated solutions for assay automation
  • Demonstrated excellence in both written and oral communication and a strong desire to lead in cross functional teams to establish productive collaborations across large portfolios
  • A strong desire to succeed in cross functional teams to establish productive collaborations