Pharmacyclics, LLC

Chemical Development Lab Manager

Location
Sunnyvale, CA, United States
Posted
Nov 14, 2018
Ref
2496
Hotbed
Biotech Bay
Required Education
Associate Degree
Position Type
Full time
Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.

More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.

General Position Summary/Purpose:

Provides a wide range of support towards Chemical Development and Manufacturing's efforts in advancing new chemical entities for the treatment of cancer and autoimmune diseases towards IND/NDA filings. Primary assignments include managing laboratory organization and other group logistics, assisting with development of scalable synthetic chemical processes, generation of sufficient amounts of compounds of interest (including lead drug candidates, intermediates, impurities, degradation products, and metabolites). Works on challenges where the analysis of situations or data requires an evaluation of various factors. Participates on interdisciplinary project teams and communicates relevant findings and future plans. Contributes to the overall R&D program.

Major Key Job Duties / Accountabilities / Core Responsibilities: (Include % Time)

Perform laboratory organizational activities such as (60% time):
  • Maintain inventory and organization of lab supplies, solvents, reagents and intermediates
  • Evaluate and obtain quotes for capital equipment and bulk reagent orders, comparing different vendors and negotiating pricing
  • Arrange shipment of materials between Chemical Development and its collaborators
  • Equipment management (perform routine maintenance and serve as point of contact for outside technicians, assist with procurement of new items and removal of obsolete)
  • Serve as point of contact for Facilities and EH&S for management of waste, obsolete chemical disposal, glassware washing and maintenance to the laboratory area

​​ Perform laboratory studies to support Chemical Development and Medicinal Chemistry efforts such as (40% time):
  • Synthesize up to hundreds of grams of non-GMP APIs, intermediates and impurities.
  • Assist with optimization of current synthetic procedures while scouting alternative routes
  • Prepare and stock typical solutions needed for Chemical Development's in-house laboratory work
  • Conduct literature and SciFinder searches to support lab work, compound procurement, and other efforts
  • Perform routine laboratory operations according to company safety procedures and maintain detailed scientific notebook per Pharmacyclics standards

General responsibilities include:
  • Collaborate with departments such as Analytical Chemistry, Medicinal Chemistry, Pharmaceutical Sciences, Global Supply Chain & Logistics, and Facilities
  • Prepare written progress reports and present relevant updates at project team meetings. Reports to be used in technical-transfers, invention disclosures, publications and CMC sections for regulatory submissions (IND, NDA)

Qualifications (Knowledge / Skills / Abilities):

  • Strong familiarity with the typical operations of and supporting needs of a synthetic chemistry laboratory
  • Good understanding of organic transformations and mechanisms relevant to small molecules
  • Working knowledge of current Good Manufacturing Practices (cGMPs) a plus
  • Expertise with purification and spectroscopic techniques (NMR, UV-vis, HPLC, TLC)
  • Demonstrated technical proficiency, scientific creativity, collaboration with others and independent thought Experience with technical writing

Specific Skills/Abilities:
  • Strong organizational skills and great attention to detail
  • Ability to conduct multi-step synthetic sequences, perform appropriate purifications, and acquire and interpret relevant analytical data of drug targets and intermediates, all with sound judgment.
  • Excellent verbal and written communication skills, collaborative team player, flexible to change in responsibilities, must be able to communicate effectively with all levels within Department
  • Proficiency with MS Word, Excel, Chem Draw computer programs
  • Must be flexible and able to work well both as part of a team and independently
  • Must be able to make recommendations based on sound logic and data analysis which contribute toward key decisions
  • Hands-on chemistry laboratory experience, including use and maintenance of typical equipment
  • Job may require some heavy lifting and will require proper handling of chemicals

Management: (Include old & new org chart)

  • No personnel management responsibilities for this position

Nature of Contacts (Internal & External):

  • Will typically interact daily with lab-based personnel from both Tech Ops (specifically Chemical Development, Analytical Chemistry, and Pharmaceutical Sciences) and Medicinal Chemistry (up through seniority level of Director/Principal Scientist)
  • Will likely have brief interactions with more senior (Senior Directors and above) members of Tech Ops on a weekly basis
  • Will have varying interactions with Associates and Managers within Global Supply Chain and Logistics, Shipping and Receiving, EH&S, Facilities, IT, and Procurement

Decision Making Authority / Discretion:

  • Will independently conduct scientific experiments
  • Will independently make purchasing decisions on lab consumables and reagents in order to maintain stock
  • May independently procure quotes for equipment, services, and large specialty chemical orders for supervisor and group review

Experience:

  • 5+ years of relevant lab experience, including demonstrated background in synthetic organic chemistry and hands-on experience of working with and maintenance of typical laboratory equipment

Education Requirements (degree, certifications, etc.): Include must have and preferred

  • BS/BA in Chemistry required
  • Prior lab experience in a Biotech/Pharma setting strongly preferred

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