Sr. Associate Scientist, Upstream Process Development

Employer
Celgene
Location
Summit, NJ, US
Posted
Nov 09, 2018
Ref
1803483
Required Education
Bachelors Degree
Position Type
Full time
Other Locations:US- NJ- Summit West

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

POSITION

Sr. Associate Scientist, Upstream Process Development

SUPERVISOR

Associate Director, Upstream Process Development

DEPARTMENT

Biologics Development
PREREQUISITES

Bio/Chemical Engineering or related field, B.S. with > 6 years industry experience or M.S. with > 4 years industry experience.

This position in Biologics Process Development is to support the development of robust upstream processes for recombinant protein production. Reporting to the Head of Upstream Process Development Group, the successful candidate will perform mammalian cell culture experiments as well as evaluate innovative technologies for improved understanding of cell metabolism.

Responsibilities will include, but are not limited to, the following:

Conducting small-scale shake flask and bioreactor experiments for cell culture process optimization, which requires flexible schedule as well as some weekend work. Performing pilot scale runs with single-use bioreactor for material generation and demonstration of process scale-up Investigating and manipulating cellular metabolism for improved process understanding Developing in-house cell culture media to achieve high productivity with desired product quality Evaluating and establishing process robustness and mitigation strategy for tech transfer to internal and external manufacturing groups Providing manufacturing support and troubleshooting of large scale upstream production processes Working closely with the cell line development and downstream development groups for execution of Celgene pipeline projects Managing laboratory activities such as equipment set-up, routine maintenance and generation of SOPs Supporting new technology assessment including external collaborations for improved process understanding Writing technical summaries and development reports for efficient knowledge management

Skills/Knowledge Required:
  • Hands-on experience with shake flasks and bench-top bioreactors
  • Familiarity with operation and troubleshooting of equipment used in cell culture processes
  • Media development and/or pilot scale experience is a plus
  • Knowledge of bioreactor characterization and engineering principles
  • Basic understanding of biochemistry and cell metabolic pathway
  • Demonstrated ability to collaborate effectively within a team setting
  • Proficient in computer systems and relevant applications
  • Statistical application and programming is a plus
  • Excellent organizational and time management skills
  • Excellent verbal and written communication skills


Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.