Pharmacyclics, LLC

Manager, Health Economics & Outcomes Research (HECOR)/Real-World Evidence (RWE)

Sunnyvale, CA, United States
Nov 08, 2018
Biotech Bay
Required Education
Position Type
Full time

Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.

More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.

To learn more about us, please visit us at

Manager, Health Economics & Outcomes Research (HECOR)/Real-World Evidence (RWE)

General Position Summary/Purpose:

Reporting to the Associate Director, Health Economics & Outcomes Research/RWE, the Manager will be responsible for operationally supporting the real-world CLL disease registry, driving execution of the CLL-specific HECOR-RWE tactics/studies, developing/updating of the Budget Impact Model, and providing input into the AMCP dossier. The Manager will also be the point person for all internal processes and compliance steps. Vendor management including invoice approval will also be a key responsibility of this role. Additional responsibilities will include supporting the continued development and updating of the health-economic and real-world evidence sections of the ibrutinib core value story across histologies.

Key Accountabilities/Core Job Responsibilities:

  • With guidance and direction from the HECOR-RWE team lead, the candidate will be responsible for operationally supporting the real-world informCLL registry on behalf of Medical Affairs and will work closely with the team-lead and medical monitor to deliver analyses findings internally and in preparation for external dissemination to alliance partners and steering committee members. Responsibilities would also include working on developing the content to present the findings at various congresses and peer-reviewed journals.
  • The candidate is expected to execute on CLL-specific tactics (including retrospective database analysis, chart reviews etc.) in collaboration with various vendors. Specific tasks may include providing scientific oversight on claims analyses, chart reviews, design of systematic literature reviews and/or survey analyses conducted by the vendor.
  • The Manager will drive the development/updating of cGVHD BIM and provide AMCP dossier inputs, as needed. Specific tasks would include design and execution of excel based economic models for different economic modeling initiatives such as budget impact models, medical cost offset models/simulations for business implications, and/or cost-effectiveness models to support the brand needs.
  • The Manager is expected to co-author the write-up and review of the HECOR studies and/or model description, including relevant portions of manuscripts, abstracts, posters, slide presentations, pertinent sections of AMCP dossier, as needed.
  • The candidate will support the continued development and updating of the health-economic and real-world evidence sections of the brands core value story across histologies.
  • The candidate will lead the process and compliance initiatives on behalf of the HECOR/RWE team ensuring that the team remains compliant in the planning and execution of all deliverables.
  • The Manager is expected to lead the vendor management efforts on behalf of the team including identification, bidding process requirements, contracting, and invoice approval.
  • The candidate will be a part of the growing cross functional team comprised of HECOR/RWE, Clinical Value & Outcomes (CV&O), Market Access, Medical Affairs, Clinical Operations, Bio Metrics and Epidemiology and will also receive exposure to functioning in a joint biopharmaceutical venture.
  • This will be a full-time position and may require some travel (






  • PhD in Pharmacy Outcomes Research, Economics, Bio Statistics, Health Services Research, Epidemiology, Health Policy, Public Health or a related discipline.
  • Prior work experience related to HECOR-RWE studies is required.
  • A minimum of 2 years' experience is required. Candidates with Masters' degree with at least 5 years' experience will be considered.
  • Prior real-world registry experience is strongly preferred.
  • Must be process and detail oriented while demonstrating the ability to handle multiple projects simultaneously. Familiarity with biopharmaceutical company processes is required.
  • Knowledge of the payer and managed care landscape including value-based outcomes is strongly preferred. Deep understanding of US healthcare environment especially with respect to oncology class of medications would be plus.


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