Associate Director, Immunology & Inflammation
Reporting to the VP, Preclinical Development, the Associate Director, Immunology and Inflammation, is responsible for providing leadership to our autoimmune programs from late discovery through IND. The Associate Director will work together with other leaders to develop comprehensive plans for preclinical evaluation of Cyteir drug candidates for use in autoimmune indications. He/she will direct internal and external research efforts in selecting autoimmune disease models, and designing key in vitro and in vivo studies. The Associate Director will work closely across functions within Cyteir to ensure efficient development of small molecule candidates and to develop associated paradigms for treatment of autoimmune diseases. In addition, the Associate Director will drive company visibility by making major contributions through scientific and/or patent literature and conferences, and provide scientific expertise and advice to corporate decision makers on critical therapeutic projects, and acquisition / licensing decisions.
- Assume responsibility and leadership for Rad51/AID immunology and autoimmune programs
- Lead preclinical development through IND submission of immunology projects
- Develop strategy to design and conduct experiments applying a wide variety of scientific principles and concepts
- Identify and implement key immune and autoimmune disease models through collaborations with external partners
- Identify, engage, and manage relationships and contracts with contract research organizations to ensure program progress and success.
- Initiate academic collaborations to identify and evaluate biological mechanism, predictive biomarkers, and in vivo efficacy for the Rad51 autoimmune programs.
- Work closely with Discovery Biology and Discovery Chemistry to identify, optimize and advance new compounds for autoimmunity
- Contribute to overall strategic development of the company, especially with regard to in vivo disease models.
- Interpretation, summarization and presentation of scientific data
- Ensure preparation of study reports appropriate for regulatory submission, and support publication strategy. Participate in the development and management of relevant budgets.
- Be involved in review/due diligence of new target opportunities, and participate in their execution.
- Promote interaction between Translational Medicine and other cross functional teams, including Clinical, Operations, and Regulatory, to support all Clinical Biomarker activities.
A PhD in Immunology or related field, the Assoc. Dir. Immunology and Inflammation will have at least six years of pharmaceutical industry experience in the area of immunology. The individual will have a strong track record of accomplishment in supporting and advancing autoimmune disease projects, and success in small team leadership.
· PhD (or equivalent) in Immunology, or a related field, with at least 6 years of relevant pharmaceutical experience
· Strong record of successfully advancing projects from discovery into clinical development
· Experience working with immunology animal models for small molecule drug development
· Experience in the management of multiple, external contracts/collaborations
· Mastery of techniques in modern immunology including multi-parameter flow cytometry, immune cell profiling, and RNA and DNA sequencing methodologies
· Experienced in the use of cutting-edge molecular platforms and models for immunologic diseases
· Experience maintaining program budgets and timelines
· Excellent written and oral communication skills
The Associate Director, Immunology and Inflammation will be a dynamic and innovative scientist with a well-developed sense of teamwork and the highest scientific integrity. He or she will have the interpersonal skills required to collaborate and communicate effectively with first-rate scientific teams across the organization, and the organizational skills to successfully manage the efforts of multiple, external contractors and collaborators.
· This is an office-based position in Lexington, MA. Travel will be required up to 20%.