Senior Research Associate – Immunopharmacology

94080, South San Francisco
Oct 31, 2018
Required Education
Bachelors Degree
Position Type
Full time

Pionyr Immunotherapeutics, a privately held growing immuno-oncology company based in South San Francisco, is seeking a skilled and experienced in vivo pharmacology associate to play a key role in the discovery, validation, and development of novel therapeutics that mobilize the immune system against cancer. The candidate will be integral member of Pionyr’s in vivo pharmacology group, and will closely collaborate with project team leaders to plan and conduct in vivo and ex vivo preclinical studies. The ideal candidate will be an outstanding hands-on scientist with proven pharmacology skills, and a strong background in syngeneic tumor models.   

Specific Responsibilities include but not limited to: :

  • Contribute to antibody discovery and therapeutic development projects by conducting in vivo efficacy, PK, and PD studies using syngeneic mouse and humanized cancer models
  • Maintain cell lines using standard cell culture techniques in support of in vivo studies
  • Use standard immunology techniques, such as MACS, FACS, and ELISA, to support ex vivo analysis of cells from animal tissues Write and review SOPs, as well as technical reports
  • Oversee stocking of relevant laboratory supplies, and maintain relevant equipment Organize and present scientific results at lab and company meetings  

Minimum Requirements:

  • BS/MS in immunology or related field with at least 4 years of hands-on in vivo experience in an academia or industry environment (preferably within immuno-oncology)
  • Proficient in mouse handling and dosing skills (oral gavage, intravenous, intraperitoneal, subcutaneous, etc.) enabling the ability to independently conduct studies in mouse models assessing tumor growth and immune responses
  • Experience developing and conducting immuno-oncology syngeneic, xenograft, or humanized mouse tumor models including orthotopic implants
  • Excellent aseptic cell culture technique for handling human and murine primary cells, and cancer cell lines
  • Experience with some of the routine immunology and biochemistry techniques, such as IHC, immunoblotting, flow cytometry, fluorescence microscopy, and tissue processing
  • Excellent communication skills with the ability to work effectively in a dynamic and flexible team environment
  • Ability to maintain detailed records of experimental methods and results
  • Ability to effectively interpret and present data
  • Demonstrated proficiency in the use of software tools to support data analysis tasks (e. g., Prism, FlowJo, Word, Excel, Powerpoint)
  • Adaptability to shifting priorities and changing work assignments  

Pionyr Immunotherapeutics, Inc. offers competitive salaries, participation in company stock-incentive plans and benefits packages, in addition to a collaborative, dynamic academic-driven science environment.

Qualified candidates may submit their cv and cover to