Scientist II, Drug MOA / Molecular Biology

Employer
Celgene
Location
San Diego, CA, US
Posted
Oct 31, 2018
Ref
1803757
Required Education
Doctorate/PHD/MD
Position Type
Full time
Other Locations:US- CA- San Diego

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

The key therapeutic platforms currently under investigation leverage a broad range of biological activities that allow for the development of novel paradigm-changing therapeutics. Our discovery research teams are organized into four Thematic Centers of Excellence (TCoE), including Protein Homeostasis (PH), Epigenetics, Immuno-oncology and Inflammation & Immunology. Within each these areas, discovery research, translational research, and early clinical development are integrated into a single team.

Summary/Scope:

The PH TCoE is built on our legacy IMiD drugs, which exhibited therapeutic efficacy in erythema nodosum leprosum, myelodysplastic syndrome, and multiple myeloma. This class of drugs hijack the cereblon E3 ubiquitin ligase to eliminate disease-driving proteins that are otherwise considered "undruggable". The early drug discovery team in the PH TCoE is now seeking a motivated PhD scientist to assist the development of cereblon modulating agents that target novel cereblon neosubstrates for ubiquitination and degradation for the treatment of a variety of human diseases. The successful candidate will develop and utilize state-of-art biotechnology tools to identify novel substrates and perform target validation for the relevant disease indication. The successful candidate will work collaboratively in a multi-disciplinary environment, and will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.

Responsibilities will include, but are not limited to, the following:
  • Generate testable hypotheses, design research protocols and execute experiments
  • Lead genome-wide and focused CRISPR screens
  • Utilize CRISPR and RNAi to determine the disease relevance of novel cereblon substrates
  • Perform cellular experiments to help define the SAR of cereblon modulators
  • Utilize genetic and pharmacological approaches to define the MOA of candidate agents
  • Design and develop novel assays
  • Document, interpret and troubleshoot results
  • Convey data analysis and interpretation to supervisor and colleagues
  • Communicate with peers and supervisors and foster teamwork
  • Contribute to collaborative efforts
  • Strong commitment to quality and reproducibility
  • Demonstrate adaptability
  • Supervise or guide research staffs


Qualifications:

Ph.D. in Molecular and Cell Biology, Biochemistry or related scientific discipline with at least 4 years of relevant work experience. Strong publication record in major scientific journals is required.

Skills/Knowledge Required:
  • Extensive wet-lab experience with routine molecular, cellular and genetic biology tools
  • Experience with CRISPR-Cas9 mediated gene editing
  • Experience with genome-wide CRISPR screens is preferred
  • Extensive training in cancer biology
  • Research experience in hematologic malignancies is preferred
  • Highly motivated and strong team player with a high degree of independence
  • Innovative and critical thinking
  • Excellent time management and organizational skills
  • Strong communication skills, both written and oral


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BIO-US

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.