Bristol-Myers Squibb Company

NGS Research Scientist

Location
Hopewell, NJ, US
Posted
Oct 31, 2018
Ref
R1511262
Required Education
Bachelors Degree
Position Type
Full time
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Job Description:

The BMS Clinical Genetics and Genomics Group is seeking a NGS Research Scientist to lead the development, validation, implementation, and growth of Next Generation Sequencing (NGS) technology to support the company's pipeline across all active therapeutic areas with an emphasis on Oncology and Immunoscience. The group is responsible for the application of relevant technologies to measure specific genetic or genomic endpoints in clinical studies which support 1) mechanism of action hypotheses, 2) pharmacokinetic/pharmacodynamic evaluations, and 3) patient stratification or 4) novel biomarkers related to clinical response. He/She will liaise closely with various stakeholders to ensure implementation of the appropriate genetic and genomic assays in early clinical studies and serve as a genomics subject matter expert for clinical programs. The position will involve leading and mentoring a team of scientists in a direct or matrix mentoring role.

Job duties:
  • Drives the implementation and growth of NGS technology, supports ongoing development, validation and troubleshooting of NGS assays, including targeted DNA-seq and RNA-seq, WES, and WGS.
  • Oversees operations of different NGS workflows; from sample preparation, library construction, data generation, data processing to interpretation of results, ensuring a high level of quality and reliability of generated results.
  • Implements data processing and analysis workflows in alignment with colleagues in bioinformatics bioinformatics pipelines, and data storage procedures in collaboration with internal and external multidisciplinary teams.
  • Effectively manages available resources, distributes assignments and delegates workload as needed to achieve timely execution of projects, works with cross functional teams (internal and external teams) to execute plans and set deliverables.
  • Serves as a subject matter expert for NGS technology, provides guidance on experimental design, method or platform selection, and data management to address a specific need.
  • Educates laboratory staff and/or contractors, conducts hands-on training, and delivers internal and external presentations.
  • Learns various NGS platforms, stays on the top of the scientific and technical innovations, and follows new trends and developments in genomic technologies to uphold BMS's competitive advantage.
  • Drafts experimental plans, validation reports, work instructions, technology transfer documents, study summaries and SOPs.
  • Actively participates in internal/external collaborations, portfolio management groups and clinical study and biomarker execution teams.


Minimum requirements:

The candidate must have experience in clinical genomics and genomics biomarker teams in a relevant scientific field, such as molecular biology, genetics and genomics, biochemistry, or other related disciplines, ideally in a pharmaceutical, biotech or clinical diagnostics industry.
  • Masters Degree with 7 years experience, PhD with 5 years experience or a Postdocural
  • Must have at least 2-3 years of documented hands-on experience with clinical and diagnostic NGS assay development, validation, troubleshooting.
  • Must have an in-depth knowledge of different NGS platforms and technologies.
  • Technical expertise with molecular diagnostic tests such as qPCR, PCR, digital PCR, Nanostring and other relevant genomics diagnostic platforms are highly desired.
  • Must have strong organizational and interpersonal skills, must display excellent leadership and people skills, and demonstrate ability to work collaboratively with others in a highly matrixed environment.
  • Mentoring and team building abilities will be highly valued.
  • Must be familiar with different NGS software platforms, bioinformatics pipelines and NGS data processing and interpretation solutions.
  • Ability to analyze and QC data in conjunction with a dedicated bioinformatics team will be desirable.
  • Must be self-motivated, with a demonstrated ability to work independently and learn quickly.
  • Must be goal oriented and focused on completing work on time.
  • Must be able to quickly adapt to changing priorities and work well in fast pace environment and under pressure.
  • Must possess good communication and presentation skills.