Senior Scientist, Cryo-EM
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is currently recruiting for a Senior Scientist, Cryo-EM . This role is within the Structual Sciences Group at Merck Research Laboratories and will be located in Kenilworth NJ USA and may require up to 10% domestic and international travel.
This role will support drug discovery through the use of atomic resolution single particle cryo-EM to determine the structure of therapeutically important targets. You will join our growing cryo-EM team and be responsible for all aspects of the single particle cryo-EM process, from sample preparation and data collection through 3-D reconstruction and will work in collaboration with medicinal and computational chemists. You will work closely with molecular biologists, biochemists and biophysicists for sample optimization.
This role will have productive and collaborative interactions with other members of the global, cross-functional department are required. There is an expectation for periodic travel to other locations. Cooperative and collaborative use of internal expertise and resources will be essential to success. The position requires active interaction with the external scientific community to continually improve scientific understanding, including presentations at national or international meetings.
Consistently cited as a great place to work, Merck employs talented people who discover, develop, manufacture, and market a wide range of vaccines and medicines to address unmet medical needs. Each of us is joined by an extraordinary sense of purpose — bringing Merck’s finest achievements to people worldwide. The Merck Kenilworth campus is located within commuting distance from NYC. This close proximity allows for close interactions with the quickly expanding high resolution single particle cryo-EM community as well as the structural biology field at large, giving easy access to the latest developments in the field.
Required Experience and Skills:
- A minimum of a PhD degree.
- A minimum of 2 years postdoctoral training in cryo-EM.
- Demonstrated experience in a broad range of activities involving atomic resolution single particle Cryo-EM, such as sample preparation, data collection, image processing and 3-D reconstruction.
- Must have excellent communication skills (written, presentation and oral).
- Strong publication record.
Preferred Experience and Skills
- Demonstrated potential to develop project management skills and identify/develop new areas of scientific expertise in cryo-EM.
- Experience with the cryo-EM microscope setup, operations and maintenance. Experience with hardware and software related to EM methods or relevant experience with other electron microscopy techniques (for example SEM or tomography).
- Experience with biophysical and functional characterization methods (e.g. SPR, thermal shift and calorimetric assays) to guide construct design and optimization of solution conditions for successful structural outcomes.
Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.
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Employee Status: Regular
Travel: Yes, 10 % of the Time
Number of Openings: 1
Shift (if applicable):
Hazardous Materials: Biochemistry and chemistry lab reagents.
Company Trade Name: Merck
Nearest Major Market: New York City
Nearest Secondary Market: Newark