Research Associate II-Chemist

Location
Bethesda, Maryland, United States
Posted
Oct 26, 2018
Ref
req111
Hotbed
BioCapital
Required Education
Bachelors Degree
Position Type
Full time
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

KEY ROLES/RESPONSIBILITIES

The Research Associate II - Chemist will:
  • Work in support of the FNL/NCI RAS Initiative and work closely with a highly collaborative multidisciplinary team of chemists, biochemists, structural and cell biologists
  • Develop and optimize agents for use as RAS inhibitors
  • Provide synthetic support during hit validation studies
  • Conduct hit-to-lead chemistry efforts around those targets/screens that yield advanceable hits

BASIC QUALIFICATIONS
  • Possession of a Bachelor's degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency
  • In addition to the educational requirement, a minimum of five (5) years of experience in organic synthesis or related field
  • Ability to keep accurate records of experiments and data
  • Capable of presenting findings at regular team meetings
  • Must be able to obtain and maintain a clearance

PREFERRED QUALIFICATIONS
  • Expertise in the design, synthesis, and characterization of pharmaceutically relevant small molecules
  • Experienced in multistep organic synthesis and the handling of air/moisture sensitive materials
  • Familiarity with modern analytical technologies including: LCMS, NMR (1H, 13C, 2D techniques), HPLC, IR, Flash chromatography
  • Experience with the design and preparation of small-molecule compound libraries
  • Basic knowledge of cancer biology
  • Must be highly collaborative, self-motivated, and team-oriented
  • Must have excellent oral and written communication skills