Eli Lilly and Company

Biologist-InVivo Incretin Discovery

Location
Indianapolis, IN, United States
Posted
Oct 24, 2018
Ref
45550
Discipline
Science/R&D, Biology
Required Education
Bachelors Degree
Position Type
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Responsibilities
The Lilly Diabetes and Complications Research organization has created a research team focused on discovery and preclinical development of new therapeutics in the areas of Incretin Discovery. The Incretin Discovery team is looking for an experienced in vivo pharmacologist with proven record of accomplishment in drug discovery and development. Do you have an in depth understanding and experience in the development, validation and implementation of in vivo assays with which to develop new therapeutics? Do you have skills to coordinate rodent studies in a team environment to support both small and large molecule projects? Your primary responsibilities will include performing proof-of-concept studies, in vivo assay development and optimization, and execution of studies (both internal and with external partners). You will have the opportunity to work in collaboration with the Incretin and Insulin Discovery groups in a team-oriented environment and to support other groups in the Diabetes and Complications Therapeutic Area with expertise as needed.

Key Objectives/Deliverables
  • Perform acute and chronic in vivo studies (glucose and insulin tolerance tests, etc.) including animal handling, blood and biopsy collection, measurement of body weight and food intake as well as test article formulation and administration by oral gavage and subcutaneous, intravenous, and intramuscular injection.
  • Assessment of meal patterning, body composition analysis, respiratory quotient and other parameters of body weight regulation
  • Perform small animal surgical procedures including, but not limited to, rodent catheter and mini pump implantation.
  • Requirement for accurate record keeping, independent data analysis, and reporting of data in written and oral formats.
45550BR

Basic Qualifications
  • Bachelor's Degree in biology or a closely related field
  • Laboratory research experience preferred
  • Qualified candidates must be legally authorized to be employed in the United States. Lilly does not anticipate providing sponsorship for employment visa status (e.g., H-1B or TN status) for this employment position.


Additional Skills/Preferences
  • Expertise in handling small laboratory animals
  • Familiar with setting up and running biochemical assays (protein, glycogen, enzyme assays, etc.), running ex vivo primary tissue assays and with aspects of protein analysis (SDS-PAGE gels and western blotting).
  • Experience and willingness to work with radioisotopes, chemical, and biological hazards.
  • Proven ability to work in flexible, team-oriented environment.
  • Experience in diabetes and/or metabolic diseases is preferred.
  • Oral/written communication/listening skills in English are essential.
  • Strong relationship-building and interaction skills with peers and management.
  • Master's degree in Biology or related field


Additional Information
  • Flexible scheduling is a requirement. The position is full-time (40 hrs/wk), but not all regularly scheduled work hours will occur Mon-Fri from 8 AM-4:45 PM. There is a requirement to work after-hours or on weekends on occasion.
  • The position level will be commensurate with the candidate's experience. The position is governed by regulations including OSHA, AAALAC, OLAW and NRC - compliance to all applicable regulations is mandatory.
  • Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.