Scientist II

Location
Frederick, MD, USA
Posted
Oct 24, 2018
Ref
JR115-21022
Hotbed
BioCapital
Required Education
Doctorate/PHD/MD
Position Type
Full time
The Laboratory of Molecular Pharmacology uses retinoic acid nuclear receptor (RAR, retinoid) and retinoid X receptor (RXR, rexinoid) agonists or antagonists as well as other agents as molecular pharmacologic tools to discover critical antineoplastic pathways. The team engages clinically-relevant cellular and engineered mouse models along with patient-derived databases to identify the deubiquitinase USP18 as a compelling drug target in oncology and conducts screens to find an inhibitor to USP18. An ongoing focus of this laboratory is to elucidate the precise signals that trigger anaphase catastrophe before moving this work into the cancer clinic.

KEY ROLES/RESPONSIBILITIES

The Scientist will:
  • Independently conduct research project, including generating hypothesis, designing projects, conducting experiments, analyzing data, writing manuscript and publishing
  • Independently conduct experiments using biochemistry, molecular biology and pharmacologic approaches and methods
  • Present research project in scientific community
  • Ensure effective operation of laboratory equipment and serve as the point of contact for instrument repairs
  • Direct, coordinate, and maintain an adequate inventory of research lab glassware, materials, and laboratory equipment
  • Organize and participate in vendor negotiations, product and software evaluations, tutorials and facility modifications


BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
  • Possession of a Doctoral degree from an accredited college or university according to the Council for Higher Education Accreditation in a field related to pharmacology, molecular pharmacology, experimental therapeutics, cancer therapy or drug development. Foreign degrees will be evaluated for U.S. equivalency
  • In addition to the education requirement, a minimum of 2 years of postdoctoral experience in cancer research, pharmacology, or other human disease research
  • Ability to conduct experiments using biochemistry, molecular biology, and other methods (hands-on experience)
  • Must be able to obtain and maintain a clearance


PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:
  • Experience in a laboratory management
  • Experience in pharmacology or cancer biology research
  • Multiple first-authored publications in peer-reviewed scientific journals
  • Multiple co-authored publications in peer-reviewed scientific journals


Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)