Bioinformatics Scientist

Frederick, MD, USA
Oct 24, 2018
Required Education
Position Type
Full time
The Clinical Pharmacodynamic Program (CPP) is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program (DTP) and the Experimental Therapeutics Clinical Trials Network (ETCTN) of the National Cancer Institute (NCI). The CPP has recently been expanded to include support for the CTP immune-oncology program. The scope of work is broad and includes assay design, development, validation, fitness for purpose testing, transfer and support of assays in internal and external clinical laboratories, and clinical specimen analysis when required. PADIS, the assay implementation laboratory, is a fast-paced multi-disciplinary environment that applies state of the art quantitative immunoassays platforms to fulfill its mission.


The Bioinformatics Scientist will:
  • Design, implement, and maintain clinical/preclinical assay, image and specimen tracking databases
  • Contribute to the science of biomarker identification and measurement in clinical trials
  • Support the structure, use, integrity, and security of local area networks storing diverse assay and image data
  • Support external and internal user issues and provide regular database status updates
  • Help to establish, implement, and maintain standard data management processes and SOPs and related working practices
  • Assist in planning, selection, and implementation of new computer/software systems
  • Complete training in existing and newly implemented data management systems, develop training material and provide user training and support as needed
  • Use bioinformatics tools, statistical methods and computer programs to collect, organize and analyze data for optimal retrieval and presentation of summarized results
  • Support the design, development, and implementation of customized electronic Case Report Forms (eCRF) for diverse pharmacodynamic assay data platforms


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
  • Possession of a Doctoral degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in a field related to bioinformatics or biomedical research with a focus on biomarkers. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
  • In addition to educational requirements, candidates should have two (2) or more years of competent, innovative research experience beyond doctoral training in a related field of specialty.
  • Must be able to obtain and maintain a security clearance


Candidates with these desired skills will be given preferential consideration:
  • The ideal candidate would have a combination of education and experience in both bioinformatics and biomarkers
  • Prior experience with protein biomarkers, biochemistry, pharmacology and/or immunology is strongly preferred
  • Working knowledge of digital pathology software systems, such as Aperio eSlide Manager and/or Indica Labs HALO
  • Knowledge of image analysis software such as Definiens Tissue Studio or Definiens Developer
  • Knowledge of immunoassay formats and platforms such as Luminex, slide-based Immunofluorescence assays, flow cytometry, and RT-qPCR and circulating tumor cell platforms
  • Ability to work in Spotfire or similar data aggregation and analysis platforms
  • Working knowledge of Medidata Rave or similar EDC system
  • Strong working knowledge of database concepts
  • Experience programming in SQL and/or SAS
  • Experience with D360 Data Informatics Platform
  • Proficiency in MS Office suite, especially Microsoft Excel

Expected Competencies:
  • Organized, detail oriented professional with strong working ethic and ability to effectively multitask
  • Outstanding English language communication skills are required, both spoken and written
  • Ability to effectively communicate with program leads and support staff in a demanding scientific environment
  • Ability to work well in a diverse team setting

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)