Proteomics & Protein Mass Spectrometry Scientist
The Analytical Science & Imaging Department is looking for a highly motivated scientist with experience in protein mass spectrometry/quantitative proteomics to be part of a proteomics team committed to support innovative drug discovery efforts. The successful candidate will work in a matrix team environment, performing LC/MS based proteomics experiments to answer key scientific questions from NIBR project teams. Qualified candidates will possess a M.S. degree in analytical chemistry, biology or related field with at least 5 years of working experience of protein mass spectrometry and proteomics. This candidate will be responsible for independently conducting experiments from sample preparation, LC-MS/MS to data analysis & interpretation. We are looking for a candidate who can utilize strong technical and organizational skills and has an enthusiastic, collaborative spirit.
Direct interaction with project teams, ability to translate key scientific questions to essential proteomics experiments, design the study jointly with project team collaborators. Perform the proteomics study independently. Deliver impact.
A master degree in biology, analytical chemistry or related field with 5+ year experience in protein mass spectrometry and proteomics including, but not limited to the following key areas: quantitative proteomics (TMT, SILAC, label free), protein post-translational modification analysis, protein-protein-interaction analysis, and targeted PRM analysis Experience in protein isolation from cells, tissue and biofluids, immuno or chemical affinity enrichment to selectively enrich proteins from complex biological samples.
Demonstrated expertise in multi-dimensional LC fractionation and high throughput quantitative proteomics. Extensive hands on experience in developing and performing proteomics experiments, nano LC-MS/MS, and analysis and interpretation of LC-MS/MS data using public and commercially available software. Experience with statistical analysis (ANOVA, experimental design) is a plus. • The ability to translate biologists/project teams scientific questions into analytical strategies and methods. Critical and independent thinking. Strong analytical and problem solving skills Excellent communication and interpersonal skills to work in a collaborative, matrix environment. Readily speaks up and share results within multi-disciplinary teams. Excellent oral and written communication skills.
Additional, highly desirable qualifications
Experience with cell culture, cell line engineering and molecular biology
Experience with various affinity purification methods including proximity based labeling technologies such as BioID
Experience with handling of clinical samples
Knowledge of structural biology and crosslinking technology
Experience with automation and liquid handling systems
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.
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