Associate Scientist I, Molecular Biology

Employer
AbbVie
Location
South San Francisco, CA, US
Posted
Oct 17, 2018
Ref
1807589
Required Education
Bachelors Degree
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at Stemcentrx, AbbVie's South San Francisco, CA location.

Associate Scientist I/II - Molecular Biology

As part of a talented and multi-disciplinary team advancing exciting new approaches to drug discovery and development, AbbVie Stemcentrx is looking for a highly motivated scientist to support lung cancer target discovery and validation. AbbVie is a global, research-based biopharmaceutical company with a strong focus in oncology and its subsidiary Stemcentrx is a leader in identifying novel cancer stem cell targets and developing targeted antibody drug conjugate (ADC) therapies in oncology. The successful candidate will be a key contributor to advancing novel lung cancer therapies into the clinic. The team's responsibilities include validating antibody drug conjugate (ADC) therapeutic targets by elucidating the biology of these targets in lung cancer.

Key Responsibilities Include:

  • Lead experimental workflow to generate, maintain, and characterize a patient derived xenograft (PDX) bank of lung tumors to aid in therapeutic target identification and validation
  • In vitro cell culture experiments including functional validation of lung cancer targets, through studying the downstream effects of knockout/knockdown, overexpression and/or inhibition of potential targets
  • Execute antibody staining of tumor cells in flow cytometry experiments, including cell sorting to isolate subpopulations of cells
  • Perform cell and molecular biology techniques including on liquid handler/high-through-put platforms
  • Independently plan, execute, analyze and troubleshoot experiments
  • Document experimental activities and data analysis thoroughly and accurately in electronic notebook
  • Actively participate in internal scientific meetings including presenting data


Basic:

• B.S. degree with hands on laboratory research experience, preferably in molecular or cellular biology or a related field

• General knowledge of cancer biology and key pathways altered in tumors

• Familiarity with best practices for culturing mammalian cells using aseptic technique

• Experience performing flow cytometry and cell sorting is required

• Molecular biology skills including western blotting, nucleic acid extraction and PCR

• Good laboratory notebook practices and attention to detail

• Eager to learn new laboratory techniques, a positive "can-do" attitude, and

Effective communication skills, both verbal and written, and ability to work collaboratively with team

• Basic knowledge analyzing biological data using Microsoft Excel, FlowJo and GraphPad Prism

Equal Opportunity Employer Minorities/Women/Veterans/Disabled