Bristol-Myers Squibb Company

Research Investigator in Immunoscience Drug Discovery - Cellular Immunology and Pharmacology

Location
Princeton, NJ, US
Posted
Oct 15, 2018
Ref
R1509810
Required Education
Doctorate/PHD/MD
Position Type
Full time
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

The successful candidate will be responsible for running an independent program in the discovery of novel treatments for diseases having disregulated immunity, primarily autoimmunity but also including tumor immunology. Responsibilities include investigating the cellular immunology and pharmacology of targets and agents in relation to human disease. This investigator will work independently and provide oversight of the design, execution and interpretation of biochemical and cellular assays, as well as in vivo pharmacology studies, in support of our Discovery efforts to identify and nominate agents for clinical development. This role requires a close working relationship with other scientists within a multi-disciplinary drug discovery team.

Qualifications:

Ph.D. in Cellular Immunology or a related field, with 3-5 years of postgraduate research. Experience in immunology-based drug discovery in an industry setting (pharma or biotech) would be a great advantage, but not required. Knowledge of adaptive and innate cellular immunology and immune tolerance including, but not restricted to, the role of T and B lymphocytes, innate lymphoid cells, and dendritic cells in the regulation of immunity is a must. This position requires both a strong understanding of how disregulated immunity drives human disease pathobiology, as well as expertise in functional cell-based assays such as T-cell, B-cell and dendritic cell differentiation, proliferation, and function, as well as receptor binding and occupancy, and cellular signaling using appropriate biochemical, cellular and pharmacological techniques. Extensive experience with aseptic isolation and culture of rodent and human primary cells and FACS-based characterization of the same is also a requirement. Familiarity in the analysis of genomics-based studies would also be of value.

Excellent communication, collaboration and leadership skills, along with a strong publication record in peer-reviewed journals, are considered key qualifications. Experience in supervisory responsibility would be preferred, but not required.