Sr Res Assoc II, Biomarker
We are seeking a highly motivated experienced individual to join the Biomarker Sciences Dept. to take the lead in biomarker assay development, qualification, and assay transfer to support clinical programs in all therapeutic areas at Gilead.
Specific Responsibilities and skills for Position
The successful candidate will be able to work independently to review literature reports and to gather input from internal colleagues and translating the information into experiments designed to address specific scientific questions and/or biomarker assay development/qualification issues, and project needs. The candidate is expected to select the most appropriate technique and methodology to execute complex experiments at the highest quality standards and in a timely manner. The candidate is expected to analyze and review the experiment data critically, to benchmark data with a third party source if available, and to come up with suggestions on the next steps. The candidate is also expected to be able to present his/her experimental data in group meetings. The candidate will also need to facilitate the drafting of assay procedure and to correspond, when needed, to vendor lab on assay transfer issues. The individuals will need to have hands on experience in immunoassays including ELISA-based methods (e.g. including but not limited MSD, Luminex), FACS based assay and/or gene transcript based molecular assays (rtPCR/nanostring, genomic based assays etc). Experience in multi-color flow cytometry (e.g whole blood immunophenotyping and intracellular cytokine and phopsho-protein expression in PBMCs) is highly preferred. In addition, the candidate will also participate in new assay platform evaluation.
Independently plans and executes assigned experiments that support non-routine research activities and project goals.
Applies advanced level of understanding project goals and methods.
Selects appropriate methods and techniques in performing experiments.
May design new experiments to advance scientific knowledge of drug substances or techniques to identify such substances.
Recommends alternatives, researches new methods and techniques and may proactively seek out senior personnel to discuss potential solutions to problems.
May lead functional group meetings. Presents results of work, interprets data, and draws conclusions regarding presented material and nature of work.
Works independently and determines methods and techniques on new or difficult assignments.
Works on complex problems where analysis of situations or data requires comprehensive evaluation of many factors.
Acts as a resource for other employees within the department.
Maintains high level of expertise through familiarity with scientific literature and applies appropriately to research projects.
Uses strong communication skills (both verbal and technical) and interpersonal skills to communicate objectives and results.
Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.
Knowledge, Experience and Skills
8+ years of experience with BS degree in a related scientific discipline.
4+ years of experience with MS degree in a related scientific discipline.
• Excellent verbal communication and interpersonal skills are required. Must be able to multi-task, work on a number of diverse projects at the same time, and communicate effectively internally in Biomarker Group and externally with other functional groups in Research and Clinical Development.
• Experience in biomarker assay development and qualification and analysis of clinical samples is highly desired.
• Strong laboratory experience in preclinical biomarker discovery/validation and/or implementing biomarker assays in a clinical trial setting are highly desired
• Experience implementing a broad array of platforms and technologies to support a clinical research program is preferred
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