Research Associate 3, Translational Research
Tocagen is a clinical-stage, cancer-selective gene therapy company focused on developing first-in-class, broadly applicable product candidates designed to activate a patient’s immune system against their own cancer from within.
Every member of our team plays a significant role in our success. Tocagen hires individuals who share our passion for ending cancer mortality and have exceptional talent that will contribute to this goal.
The Research Associate will be responsible, with minimal supervision, for the execution of in vivo scientific research experiments relating to cancer gene therapy research and characterizing host and viral factors involved in susceptibility and resistance to viral delivery, infection, and spread. Specific duties include conducting in vivo experiments using existing models and participating in establishing new animal model capability to support the development and analyses of replicating retroviruses for preclinical product development
Duties and Responsibilities Include But Are Not Limited To:
Understand the goals of the Translational Research group and their relationship to strategic R&D and corporate goals and objectives.
Develop personal goals and maintain strategies to meet such goals within set timeframes.
With team members, plan and execute collaborative research experiments requiring initiative and judgment within defined procedures and practices; exercise judgment and show initiative in making technical decisions.
Work on problems of defined scope with minimal supervision identify, analyze, and interpret experimental results. Prepare written reports of scientifically/technically complex experiments and participates in oral presentation at the R&D meetings on all phases of laboratory and/or field experimental work.
Conduct experiments and prepare written reports conforming to defined documentation practices in support of regulatory filings and other company documents including well documented notebook.
Comply with the company safety policies and minimize risk to self, others and the environment, consistent with the community and industry standards. Performs other duties as required.
Desired Knowledge and Abilities:
Established knowledge of discipline including knowledge of protocols, scientific method and its applications, and use of specialized equipment (examples include IVIS imaging and stereotactic devices).
Demonstrated potential for technical proficiency and creativity, collaboration with others and independent thought. Excellent verbal/written communication skills and proficient computer skills including word processing, spreadsheet, and data base programs.
Demonstrated technical capability; enjoys working in a fast paced dynamic environment. Significant experience with in vivo techniques including tumor models, necropsy, small animal surgery, drug administration, tissue and fluid sampling.
Significant experience with intracranial cannulations or intracranial implantations in murine models.
Familiarity with cell culture, immunohistochemistry, immunological and/or molecular biology techniques.
Flexible and cooperative spirit with strong commitment to team efforts.
Education and Experience:
BS/4+ years or MS/2+ years of experience or equivalent in cancer biology or related scientific discipline
Minimum 2 years of industrial experience. Technical documentation experience is a plus.
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
While performing the duties the employee is:
Constantly required to sit, and to reach to use computers and other office equipment occasionally stand for extended periods of time, up to four (4) hours/time. occasionally required to lift up to 25 pounds constantly required to view objects at close and distant ranges frequently required to communicate with others
Employee frequently works in a professional office environment and computer lab with lots of computer equipment, machinery, tools, and moderate amounts of noise and activity. Employee may occasionally be exposed to fumes, airborne particles, toxic chemicals, vibration, and biohazardous materials. The work environment is fast-paced and demanding. This position has the utmost responsibility for compliance with the rules and regulations regarding a safe and healthy work environment relative to their actions and conduct. Off-shift, weekend and overtime duties may be required as assigned by the lead operator or manager.