Scientist II, Research Biology

Location
San Francisco, CA, United States
Posted
Oct 06, 2018
Ref
3354-360-R
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time
Position Overview

We are currently seeking a highly motivated and creative Scientist II/Senior Scientist to join the In Vivo Pharmacology team in Research Biology with a focus on inflammation and immunology in our San Francisco site.

This individual will focus on mechanistic pharmacology and functional biology with emphasis on in vivo immunology/inflammation related models. The Scientist will conceive experimental design strategies to characterize novel targets, to test efficacy of potential therapeutics, and to develop relevant mechanism of action studies to support target validation and nonclinical development. The Scientist is expected to lead and participate in the conduct of experiments in various in vivo immunology/inflammation related models. We are seeking someone who is a hands-on expert in relevant experimental biology techniques in addition to in vivo modeling, including also ex vivo techniques like tissue-derived primary cell flow cytometry and functional in vitro and ex vivo immune cell assays that evaluate mechanistic aspects of immune modulation and cell signaling by potential drug candidates in diverse test systems. A strong immunology background is required. This individual will lead technology development in the area of in vivo autoimmune and inflammatory disease modeling and experimental drug testing to support early discovery and preclinical development of pipeline assets. Additionally, s/he will interpret and communicate experimental findings and documents according to approved Nektar policy. We are seeking someone who maintains a broad knowledge of state-of-the-art principles and theories, and develops and analyzes new product concepts by reviewing nonclinical and clinical literature. The Scientist may lead discovery teams, as necessary, act as a Pharmacology functional representative on functional and development teams, as well as manage junior scientists and research associates. This position contributes to and supports the company's research and development efforts to create high value therapeutics to address unmet medical needs.

Expertise in state-of-the art in vivo immunology/inflammation related animal models and ex vivo immune cell analysis with clear impact on throughput and project progression. Must have expertise with specific assays and models used for immunological functional evaluation of therapeutic candidates. Leads in the use of professional and scientific concepts to contribute to the development of company concepts and principles to achieve objectives in creative and effective ways. Synthesizes multiple data sources and draws general, non-obvious conclusions. Defines complex problems, develops approaches and develops experiments with sound judgment. Puts work practices into a context of a larger team and participates in the implementation of change when required. Ability to work collaboratively on multiple projects concurrently, and to coordinate activities with other team members and across functions. Must be able to clearly communicate scientific information both written and oral. Conversant in writing reports, protocols and deliver formal data presentations internally and externally. Ability to manage external study activities through CROs and collaborators in parallel to internal research activities. May lead staff or a group, provides training as needed, and ensures adherence to company policies and quality requirements. Works on complex problems in which analysis of situations or data requires an in-depth evaluation of various factors. Exercises judgment within broadly defined practices and policies in selecting methods, techniques and evaluation criteria for obtaining results. May determine methods and procedures on new assignments.

PhD in a scientific discipline is required. Equivalent experience may be accepted. A minimum of 4 years work experience in a research and/or development environment is required. Post-doctoral work may serve as experience. Exceptional non-PhDs with demonstrated capabilities and/or significant experience may also be considered. Prior experience in inflammatory and autoimmune diseases is required. Additional requirements include: Must be able to demonstrate significant success in technical proficiency, scientific creativity, collaboration with others and independent thought. Must be current and active in the field, while able to demonstrate expert knowledge in scientific principles and concepts both internally and externally with sustained performance and accomplishment. Must be able to compose sound written work. Must be willing to work as part of a team. Must be able to demonstrate good interpersonal skills. Strong organizational and hands-on research skills are required. Strong computer skills are required including a working knowledge of MS Word, Excel, Powerpoint and GraphPad Prism. Experience working in a FDA regulated environment and knowledge of current GMPs as they apply to laboratory and clinical practices is preferred. Performance of tasks essential to the job function may require the employee to work directly with, handle, or otherwise come into contact with chemicals or pharmaceutical agents. Employees may be required to enroll in a medical surveillance program based on the potential exposure to certain health hazards encountered as a result of their job function.

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class. Nektar Therapeutics will consider for employment qualified applicants with criminal histories in the manner proscribed by the San Francisco Fair Chance Ordinance.