Sr. Scientist II, Research Biology

Location
San Francisco, CA, United States
Posted
Oct 06, 2018
Ref
3371-363-2018
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time
Position Overview

Leads the development of experimental strategy and the design and conduct of experiments in biological systems.

The Non-clinical PK department within Nektar Therapeutics is seeking to recruit a highly motivated and experienced Senior Scientist to be responsible for large molecule bioanalysis including biomarkers in support of company's immuno-oncology and immunology programs. The successful candidate will devise and carry out bioanalytical strategies for the quantification of large molecule drug candidates, biomarkers, and anti-drug antibodies in biological matrices to support preclinical PK/PD/TK studies. This individual must be an expert in immunoassay/ligand binding assay method development, execution and troubleshooting using a variety of assay formats or technology platforms. S/he will analyze, interpret, summarize and present large molecule DMPK/BA data to project team and senior management and may write, edit, and finalize appropriate sections of regulatory filings. This position contributes to and supports the company's research and development efforts to create high value therapeutics to address unmet medical needs.

Devise bioanalytical strategies for large molecule therapeutic candidates and establish deliverables and timelines. Develop robust immunoassays/ligand binding assays for the quantification of large molecule drug candidates, biomarkers, and anti-drug antibodies in biological matrices. Oversee and conduct bioanalytical sample analysis for non-GLP PK/PD/TK studies.Analyze, interpret, summarize and present large molecule DMPK/BA data to internal project teams and senior management. Write, edit, and finalize DMPK/BA technical reports supporting regulatory filings. Stay current with the latest bioanalytical methods and technologies; identify, evaluate and implement the new technologies as needed. Serve as a liaison between Non-clinical PK and the translational group as well the regulated BA group for method transfer. May provide trainings and guidance to other junior level personnel. May assist with designing and implementing organizational processes, budgetary and capital equipment requirements, and identifies needs for additional resources.

A PhD in a scientific discipline (biochemistry / cell biology / immunology) is required. Equivalent experience may be accepted. A minimum of 8 years work experience in a research and/or development environment is required. Post-doctoral work may serve as experience.Exceptional non-PhDs with demonstrated capabilities and/or significant experience may also be considered. Must have in-depth knowledge and extensive expertise in immunoassay/ligand binding assay development, execution and troubleshooting, and conduct of large molecule bioanalysis and quantification in biological matrices. Strong background on immunoassay technologies, such as ELISA (direct and indirect sandwich formats), Luminescence, Colorimetric, Electrochemiluminescence (MSD), etc to support preclinical PK/PD/TK studies. Knowledge and experience with mass spectrometric analysis and quantification of proteins is a plus. Experience with developing automated sample handling and assay processes is desirable. Knowledge of GLP, GCP, Bioanalytical and immunogenicity guidance (FDA/EMA) is a plus. A working knowledge of large molecule pharmacokinetics and protein biochemistry and characterization would be beneficial. Must possess good oral, presentation, and written communication skills. Strong organizational skills are required. Good computer skills are required. Working knowledge of MS word, Excel and Power point. Must be willing to work as part of a team. Must be able to demonstrate good interpersonal skills. Other traits: Self-motivated, fast paced environment, able to find alternative solutions

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class. Nektar Therapeutics will consider for employment qualified applicants with criminal histories in the manner proscribed by the San Francisco Fair Chance Ordinance.