Postdoctoral Scholar - Palop Lab

San Francisco, California
Oct 06, 2018
Biotech Bay
Required Education
Position Type
Full time

The Gladstone Institutes is an independent, not-for-profit research institution affiliated with the University of California San Francisco (UCSF), contributing to the health and well-being of all people through medical research, education, and outreach in the areas of heart disease, HIV/AIDS, and neurological disease. Gladstone is composed of three separate institutes and approximately 400 employees. Our employees receive exceptional benefits. We are located in an award-winning building adjacent to UCSF's Mission Bay Campus. Gladstone has consistently ranked as one of the top places to work in academia in the United States.

A postdoctoral scholar position in the Palop Lab for an experienced and highly motivated electrophysiologist to join an interactive team that aims at understanding cellular, synaptic, and network dysfunction in Alzheimer's disease (AD), epilepsy and other neurological disorders. To study these complex diseases, our lab primarily uses mouse models that recapitulate key aspects of the cognitive dysfunction and pathology of these conditions. We use in vivo physiology in behaving mice, including electroencephalography (EEG), local field potentials (LFP), and single-unit recordings, optogenetic approaches, genetic and pharmacological manipulations, and behavioral testing to dissect network and circuits mechanisms of brain dysfunction in mouse models of AD. This position will require performing electrophysiological experiments in cultured human neurons and acute brain slices, including field and patch-clamp recordings, as well as in vivo recordings of single-unit activity and optogenetic manipulations in behaving mice. The position will be supported by a recently awarded NIH-NIA R01 that proposes to define the underlying circuits and interneuron cell types responsible for altered network activity and A deposition in mouse models of Alzheimer's disease using state-of-the-art in vivo electrophysiological techniques and optogenetic manipulations.

Postdoctoral candidates should possess a PhD, MD, or both. Please send a cover letter describing past research accomplishments and future research interests, CV, and a list of 3 references by email to Jorge Palop.