Eli Lilly and Company

Post-Doctoral Fellow-Oncology Research-FDE

Indianapolis, IN, United States
Oct 05, 2018
Required Education
Position Type
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world

Genomic correlates of sensitivity to Ras pathway and cell cycle inhibitor drugs have been identified but the mechanistic basis for some of these associations remains unclear. As a post-doctoral fellow you will investigate the mechanisms underlying the sensitivity and resistance of different genetic subtypes of cancer to one or more drugs in the Eli Lilly portfolio. Working closely with Lilly's bioinformatics, biochemistry, proteomics and clinical research groups, hypotheses will be formulated and tested to explain the clinical and pre-clinical observations. These studies are expected to lead to one or more high profile publications and to new clues to inform the clinical use of cell cycle inhibitor drugs

Key Objectives / Deliverables:
  • Examine the effects of Ras pathway and/or cell cycle drugs on key signaling pathways in cancer cells and formulate hypotheses to explain the genomic determinants of drug response
  • Identify and examine drug-drug combination strategies
  • Test hypotheses that have emerged from whole genome CRISPR screens to identify mechanisms of resistance to Ras pathway and cell cycle inhibitor drugs
  • Test hypotheses that have emerged from CRISPR screens to identify drug potentiators in the treatment of cancer

Basic Qualifications
  • PhD in cell biology, cancer biology, biochemistry, genetics or molecular biology or related discipline
  • Extensive experience with cancer cell culture

Additional Skills/Preferences
  • Skilled in basic techniques of molecular and cell biology to study signal transduction
  • Skilled in the use of computational tools and databases of gene function
  • Excellent presentation skills
  • Outstanding publication record
  • Previous experience studying the genetics of resistance and sensitivity to cancer drugs
  • Previous experience with cell cycle or RTK-Ras-MAPK pathways

Additional Information

  • Overtime and flexibility in shift may be required
  • Ability to wear safety equipment (safety glasses, safety shoes, protective gloves, respirator, etc.).
  • This position is not permanent. It is for a fixed duration of two years with potential to extend annually for up to 4 years.
  • Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status