Senior Research Associate/Associate Scientist, In vitro cellular screening
Uniquely positioned to enhance quality of life in aging, at Alkahest, we are pioneering science that is rapidly being translated to the clinic. Our approaches utilize in vivo, in vitro, proteomic, and molecular techniques to identify new therapeutics and apply them to patients.
The candidate will be key in establishing and executing in vitro assays to enable screening of novel therapeutics and elucidation of mechanism of action to advance multiple programs in our therapeutic pipeline. Therapeutic focus is primarily on disorders of the nervous system, utilizing screening assays performed with primary and secondary cell culture systems including but not limited to neurons, astrocytes, and microglia. The role is critical in assisting the scientific team in screening therapeutic targets and in advancing our therapeutic understandings. The role requires dedication, flexibility, excellent communication and organization, and will interact with a team of scientists and research associates to drive multiple projects in parallel. We offer a competitive compensation package.
We offer a competitive compensation package.
Specific responsibilities include, but are not limited to:
- Designing, performing, and analyzing cellular in vitro experiments
- Isolating, purifying, and maintaining primary cultures
- Generation and maintenance of stable cell lines
- Immunocytochemistry, microscopy and image analysis
- Biochemical and molecular analysis of cellular lysates (i.e. RT-qPCR, Western blot, ELISA)
- Maintaining familiarity with current scientific literature
- Investigating and developing new methods and technologies for project advancement
- Writing scientific reports
- Other responsibilities as assigned.
- BS/MS/PhD degree from an accredited college/university in a field related to biomedical research, cell biology, molecular biology, biochemistry, or neuroscience
- Minimum of 5 years of progressively advancing academic lab experience or 3 years of industry experience
- Experience with primary and secondary tissue cultures, immunocytochemistry, and microscopy is required
- Experience with cell-based high content screening is strongly preferred
- Experience with vector design and construction, viral expression, or conditional gene expression in mammalian systems is an advantage
- Experience with FACS is an advantage
- Ability to work collaboratively and excellent interpersonal, verbal, and written communication skills
- Attention to detail and strong organizational skills